Okebo
- Generic Name: doxycycline monohydrate capsules
- Brand Name: Okebo
Okebo (Doxycycline Monohydrate Capsules) side effects drug center
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- loss of appetite,
- nausea,
- vomiting,
- diarrhea,
- inflammation of the tongue,
- difficulty swallowing,
- inflammation in the digestive tract,
- pancreatitis,
- rashes,
- liver and kidney toxicity,
- hives,
- allergic reactions including anaphylaxis,
- anemia,
- low blood platelets (thrombocytopenia),
- low white blood cell counts (neutropenia), and
- high white blood cell counts (eosinophilia).
- anticoagulants,
- penicillin,
- antacids containing aluminum, calcium, or magnesium, and iron-containing preparations,
- barbiturates,
- carbamazepine,
- phenytoin,
- methoxyflurane, and
- oral contraceptives
What Is Okebo?
Okebo (doxycycline monohydrate) is a tetracycline antibiotic used to treat a wide variety of infections including, Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by Rickettsiae; respiratory tract infections caused by Mycoplasma pneumoniae; lymphogranuloma venereum caused by Chlamydia trachomatis; psittacosis (ornithosis) caused by Chlamydophila psittaci; trachoma, and uncomplicated urethral, endocervical or rectal infections caused by Chlamydia trachomatis; nongonococcal urethritis caused by Ureaplasma urealyticum; relapsing fever due to Borrelia recurrentis; chancroid caused by Haemophilus ducreyi; plague due to Yersinia pestis; tularemia due to Francisella tularensis; cholera caused by Vibrio cholerae; campylobacter fetus infections caused by Campylobacter fetus; brucellosis due to Brucella species; bartonellosis due to Bartonella bacilliformis; branuloma inguinale caused by Klebsiella granulomatis; infections caused by Escherichia coli, Enterobacter aerogenes, Shigella species, and Acinetobacter species; respiratory tract infections caused by Haemophilus influenzae; respiratory tract and urinary tract infections caused by Klebsiella species; upper respiratory infections caused by Streptococcus pneumoniae; anthrax due to Bacillus anthracis, including inhalational anthrax (post-exposure); uncomplicated gonorrhea caused by Neisseria gonorrhoeae; syphilis caused by Treponema pallidum; yaws caused by Treponemapallidum subspecies pertenue; listeriosis due to Listeria monocytogenes; Vincent’s infection caused by Fusobacterium fusiforme; actinomycosis caused by Actinomyces israelii; infections caused by Clostridium species. In acute intestinal amebiasis, doxycycline may be a useful adjunct to amebicides. In severe acne, doxycycline may be useful adjunctive therapy.
What Are Side Effects of Okebo?
Side effects of Okebo include:
Dosage for Okebo
The usual adult dose of Okebo is 200 mg on the first day of treatment (administered 100 mg every 12 hours or 50 mg every 6 hours) followed by a maintenance dose of 100 mg/day. The maintenance dose may be administered as a single dose or as 50 mg every 12 hours. In the management of more severe infections (particularly chronic infections of the urinary tract), 100 mg every 12 hours is recommended.
For all pediatric patients weighing less than 45 kg with severe or life-threatening infections (e.g., anthrax, Rocky Mountain spotted fever), the recommended dosage of Okebo is 2.2 mg/kg of body weight administered every 12 hours. Children weighing 45 kg or more should receive the adult dose.
Okebo In Children
Because of the effects of drugs of the tetracycline–class, on tooth development and growth, use Okebo in pediatric patients 8 years of age or less only when the potential benefits are expected to outweigh the risks in severe or life-threatening conditions (e.g., anthrax, Rocky Mountain spotted fever), particularly when there are no alternative therapies.
What Drugs, Substances, or Supplements Interact with Okebo?
Okebo may interact with other medicines such as:
Tell your doctor all medications and supplements you use.
Okebo During Pregnancy and Breastfeeding
Tell your doctor if you are pregnant or plan to become pregnant before using Okebo; it is unknown how it would affect a fetus. Tetracyclines such as Okebo pass into breast milk, however, the extent of absorption of the drugs by the breastfed infant is not known. Because of the potential for adverse reactions in nursing infants, breastfeeding while using Okebo is not recommended.
Additional Information
Our Okebo (doxycycline monohydrate) Capsules Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Okebo Professional Information
SIDE EFFECTS
Due to oral doxycycline's virtually complete absorption, side effects to the lower bowel, particularly diarrhea, have been infrequent. The following adverse reactions have been observed in patients receiving tetracyclines.
Gastrointestinal
Anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, and inflammatory lesions (with monilial overgrowth) in the anogenital region, and pancreatitis. Hepatotoxicity has been reported. These reactions have been caused by both the oral and parenteral administration of tetracyclines. Rare instances of esophagitis and esophageal ulcerations have been reported in patients receiving capsule and tablet forms of drugs in the tetracycline class. Most of these patients took medications immediately before going to bed. (See DOSAGE AND ADMINISTRATION.)
Skin
Maculopapular and erythematous rashes, Stevens-Johnson syndrome, toxic epidermal necrolysis, and erythema multiforme have been reported. Exfoliative dermatitis has been reported but is uncommon. Photosensitivity is discussed above. (See WARNINGS.)
Renal Toxicity
Rise in BUN has been reported and is apparently dose related. (See WARNINGS.)
Hypersensitivity Reactions
Urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis, and exacerbation of systemic lupus erythematosus.
Blood
Hemolytic anemia, thrombocytopenia, neutropenia, and eosinophilia have been reported with tetracyclines.
Other
Intracranial hypertension (IH, pseudotumor cerebri) has been associated with the use of tetracyclines. (See PRECAUTIONS, General.)
When given over prolonged periods, tetracyclines have been reported to produce brown-black microscopic discoloration of the thyroid gland. No abnormalities of thyroid function are known to occur.
DRUG INTERACTIONS
Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.
Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracyclines in conjunction with penicillin.
Absorption of tetracyclines is impaired by antacids containing aluminum, calcium, or magnesium, and iron-containing preparations.
Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline.
The concurrent use of tetracycline and methoxyflurane has been reported to result in fatal renal toxicity.
Concurrent use of tetracycline may render oral contraceptives less effective.
Read the entire FDA prescribing information for Okebo (Doxycycline Monohydrate Capsules)