Adoxa

Adoxa (doxycycline) is a tetracycline antibiotic used to treat many different bacterial infections, such as urinary tract infections, acne, gonorrhea, and chlamydia, periodontitis (gum disease), and others. Adoxa is also used to treat blemishes, bumps, and acne-like lesions caused by rosacea. Adoxa is available in generic form. Common side effects of Adoxa include:

• stomach upset,
• diarrhea,
• nausea,
• vomiting,
• skin rash or itching, or
• vaginal itching or discharge

The usual adult dose of oral Adoxa is 200 mg on the first day of treatment (taken 100 mg every 12 hours or 50 mg every 6 hours) followed by a maintenance dose of 100 mg/day. The maintenance dose may be taken as a single dose or as 50 mg every 12 hours. Adoxa may interact with cholesterol-lowering medications, isotretinoin, tretinoin, antacids, products containing bismuth subsalicylate, minerals such as iron, zinc, calcium, magnesium, over-the-counter vitamin and mineral supplements, blood thinners, or penicillin antibiotics. Tell your doctor all medications and supplements you use. Adoxa is not recommended for use during pregnancy. It may harm a fetus. Consult your doctor to discuss using birth control while taking this medication. This drug passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breastfeeding.

Our Adoxa (doxycycline) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

 

Adoxa Consumer Information

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. This reaction may occur several weeks after you began using doxycycline.

Call your doctor at once if you have:

• severe stomach pain, diarrhea that is watery or bloody;
• throat irritation, trouble swallowing;
• chest pain, irregular heart rhythm, feeling short of breath;
• little or no urination;
• low white blood cell counts--fever, chills, swollen glands, body aches, weakness, pale skin, easy bruising or bleeding;
• increased pressure inside the skull--severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes; or
• signs of liver or pancreas problems--loss of appetite, upper stomach pain (that may spread to your back), tiredness, nausea or vomiting, fast heart rate, dark urine, jaundice (yellowing of the skin or eyes).

Common side effects may include:

• nausea, vomiting, upset stomach, loss of appetite;
• mild diarrhea;
• skin rash or itching;
• darkened skin color; or
• vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Adoxa (Doxycyline Capsules)

 

Adoxa Professional Information

SIDE EFFECTS

Due to oral doxycycline's virtually complete absorption, side effects to the lower bowel, particularly diarrhea, have been infrequent. The following adverse reactions have been observed in patients receiving tetracyclines:

Gastrointestinal

Anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, and inflammatory lesions (with monilial overgrowth) in the anogenital region. Hepatotoxicity has been reported ^(b)(4).  These reactions have been caused by both the oral and parenteral administration of tetracyclines. Rare instances of esophagitis and esophageal ulcerations have been reported in patients receiving capsule and tablet forms of drugs in the tetracycline class. Most of these patients took medications immediately before going to bed. (See DOSAGE AND ADMINISTRATION.)

Skin

Maculopapular and erythematous rashes Stevens-Johnson syndrome, toxic epidermal necrolysis and erythema multiforme have been reported. Exfoliative dermatitis has been reported but is uncommon. Photosensitivity is discussed above. (See WARNINGS.)

Renaltoxicity

Rise in BUN has been reported and is apparently dose related. (See WARNINGS.)

Hypersensitivity Reactions

Urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis, and exacerbation of systemic lupus erythematosus.

Blood

Hemolytic anemia, thrombocytopenia, neutropenia, and eosinophilia have been reported with tetracyclines.

Other

Bulging fontanels in infants and intracranial hypertension in adults. (See PRECAUTIONS -General.)

When given over prolonged periods, tetracyclines have been reported to produce brown-black microscopic discoloration of the thyroid gland. No abnormalities of thyroid function are known to occur.

Read the entire FDA prescribing information for Adoxa (Doxycyline Capsules)