Triesence
- Generic Name: triamcinolone acetonide injectable suspension
- Brand Name: Triesence
- Drug Class: Corticosteroids, Ophthalmic
Triesence (Triamcinolone Acetonide Injectable Suspension) side effects drug center
Triesence Side Effects Center
What Is Triesence?
Triesence (triamcinolone acetonide) Injectable Suspension is a steroid injection used to treat inflammation of the joints or tendons to treat arthritis, bursitis, or epicondylitis (tennis elbow). Triesence is usually given in these conditions only as a short-term treatment of a severe or aggravated episode. Triesence is also injected into soft tissues of the body to treat certain skin disorders caused by autoimmune conditions such as lupus, psoriasis, lichen planus, and others.
What Are Side Effects of Triesence?
Common side effects of Triesence include:
- nausea
- bloating
- appetite changes
- stomach or side pain
- headache
- sleep problems (insomnia)
- acne
- scaling or other skin changes
- a wound that is slow to heal
- thinning hair
- bruising or swelling
- sweating more than usual, or
- irregular menstrual periods
Dosage for Triesence
The initial recommended dose of Triesence suspension is 4 mg (100 microliters of 40 mg/mL suspension) with subsequent dosage as needed over the course of treatment.
What Drugs, Substances, or Supplements Interact with Triesence?
Triesence may interact with birth control pills or hormone replacement therapy, blood thinners, cyclosporine, digoxin, insulin or oral diabetes medications, isoniazid, rifampin, seizure medications, antibiotics, aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs). Tell your doctor all medications and supplements you use.
Triesence During Pregnancy or Breastfeeding
During pregnancy, Triesence should be used only if prescribed. This drug can pass into breast milk and may harm a nursing baby. Do not breastfeed while you are using Triesence.
Triesence During Pregnancy or Breastfeeding
Additional Information
Our Triesence (triamcinolone acetonide) Injectable Suspension Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
Triesence Consumer Information
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- (after injection into a joint space) increased pain or swelling, joint stiffness, fever, and general ill feeling;
- blurred vision, tunnel vision, eye pain, or seeing halos around lights;
- unusual changes in mood or behavior;
- swelling, rapid weight gain, feeling short of breath;
- stomach cramps, vomiting, diarrhea, bloody or tarry stools, rectal irritation;
- sudden numbness or weakness (especially on one side of the body);
- a seizure (convulsions);
- severe headache, blurred vision, pounding in your neck or ears;
- increased pressure inside the skull--severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes; or
- signs of low adrenal gland hormones--flu-like symptoms, headache, depression, weakness, tiredness, diarrhea, vomiting, stomach pain, craving salty foods, and feeling light-headed.
Certain side effects may be more likely with long-term use or repeated doses of triamcinolone injection.
Steroids can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.
Common side effects may include:
- skin changes (acne, dryness, redness, bruising, discoloration);
- increased hair growth, or thinning hair;
- nausea, bloating, appetite changes;
- stomach or side pain;
- cough, runny or stuffy nose;
- headache, sleep problems (insomnia);
- a wound that is slow to heal;
- sweating more than usual; or
- changes in your menstrual periods.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Triesence (Triamcinolone Acetonide Injectable Suspension)
Triesence Professional Information
SIDE EFFECTS
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
Adverse event data were collected from 300 published articles containing data from controlled and uncontrolled clinical trials which evaluated over 14,000 eyes treated with different concentrations of triamcinolone acetonide.
The most common dose administered within these trials was triamcinolone acetonide 4 mg administered as primary or adjunctive therapy primarily as a single injection.
The most common reported adverse events following administration of triamcinolone acetonide were elevated intraocular pressure and cataract progression. These events have been reported to occur in 20-60% of patients.
Less common reactions occurring in up to 2% include endophthalmitis (infectious and non-infectious), hypopyon, injection site reactions (described as blurring and transient discomfort), glaucoma, vitreous floaters, and detachment of retinal pigment epithelium, optic disc vascular disorder, eye inflammation, conjunctival hemorrhage and visual acuity reduced. Cases of exophthalmos have also been reported.
Common adverse reactions for systemically administered corticosteroids include fluid retention, alteration in glucose tolerance, elevation in blood pressure, behavioral and mood changes, increased appetite and weight gain.
Other reactions reported to have occurred with the administration of corticosteroids include:
Allergic Reactions: Anaphylactoid reaction, anaphylaxis, angioedema
Cardiovascular: Bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, fat embolism, hypertrophic cardiomyopathy in premature infants, myocardial rupture following recent myocardial infarction, pulmonary edema, syncope, tachycardia, thromboembolism, thrombophlebitis, vasculitis
Dermatologic: Acne, allergic dermatitis, cutaneous and subcutaneous atrophy, dry scalp, edema, facial erythema, hyper or hypopigmentation, impaired wound healing, increased sweating, petechiae and ecchymoses, rash, sterile abscess, striae, suppressed reactions to skin tests, thin fragile skin, thinning scalp hair, urticaria
Endocrine: Abnormal fat deposits, decreased carbohydrate tolerance, development of Cushingoid state, hirsutism, manifestations of latent diabetes mellitus and increased requirements for insulin or oral hypoglycemic agents in diabetics, menstrual irregularities, moon facies, secondary adrenocortical and pituitary unresponsiveness (particularly in times of stress, as in trauma, surgery or illness), suppression of growth in children
Fluid and Electrolyte Disturbances: Potassium loss, hypokalemic alkalosis, sodium retention
Gastrointestinal: Abdominal distention, elevation in serum liver enzymes levels (usually reversible upon discontinuation), hepatomegaly, hiccups, malaise, nausea, pancreatitis, peptic ulcer with possible perforation and hemorrhage, ulcerative esophagitis
Metabolic: Negative nitrogen balance due to protein catabolism
Musculoskeletal: Aseptic necrosis of femoral and humeral heads, charcot-like arthropathy, loss of muscle mass, muscle weakness, osteoporosis, pathologic fracture of long bones, steroid myopathy, tendon rupture, vertebral compression fractures
Neurological: Arachnoiditis, convulsions, depression, emotional instability, euphoria, headache, increased intracranial pressure with papilledema (pseudo-tumor cerebri) usually following discontinuation of treatment, insomnia, meningitis, neuritis, neuropathy, paraparesis/paraplegia, paresthesia, sensory disturbances, vertigo
Reproductive: Alteration in motility and number of spermatozoa.
DRUG INTERACTIONS
Amphotericin B
There have been cases reported in which concomitant use of Amphotericin B and hydrocortisone was followed by cardiac enlargement and congestive heart failure. See Potassium depleting agents.
Anticholinesterase Agents
Concomitant use of anticholinesterase agents and corticosteroids may produce severe weakness in patients with myasthenia gravis. If possible, anticholinesterase agents should be withdrawn at least 24 hours before initiating corticosteroid therapy.
Anticoagulant Agents
Co-administration of corticosteroids and warfarin usually results in inhibition of response to warfarin, although there have been some conflicting reports. Therefore, coagulation indices should be monitored frequently to maintain the desired anticoagulant effect.
Antidiabetic Agents
Because corticosteroids may increase blood glucose concentrations, dosage adjustments of antidiabetic agents may be required.
Antitubercular Drugs
Serum concentrations of isoniazid may be decreased.
CYP 3A4 Inducers (e.g., barbiturates, phenytoin, carbamazepine, and rifampin)
Drugs such as barbiturates, phenytoin, ephedrine, and rifampin, which induce hepatic microsomal drug metabolizing enzyme activity may enhance metabolism of corticosteroid and require that the dosage of corticosteroid be increased.
CYP 3A4 Inhibitors (e.g., ketoconazole, macrolide antibiotics)
Ketoconazole has been reported to decrease the metabolism of certain corticosteroids by up to 60% leading to an increased risk of corticosteroid side effects.
Cholestyramine
Cholestyramine may increase the clearance of corticosteroids.
Cyclosporine
Increased activity of both cyclosporine and corticosteroids may occur when the two are used concurrently. Convulsions have been reported with concurrent use.
Digitalis
Patients on digitalis glycosides may be at increased risk of arrhythmias due to hypokalemia.
Estrogens, Including Oral Contraceptives
Estrogens may decrease the hepatic metabolism of certain corticosteroids thereby increasing their effect.
NSAIDS Including Aspirin And Salicylates
Concomitant use of aspirin or other non-steroidal antiinflammatory agents and corticosteroids increases the risk of gastrointestinal side effects. Aspirin should be used cautiously in conjunction with corticosteroids in hypoprothrombinemia. The clearance of salicylates may be increased with concurrent use of corticosteroids.
Potassium Depleting Agents (e.g., diuretics, Amphotericin B)
When corticosteroids are administered concomitantly with potassium-depleting agents, patients should be observed closely for development of hypokalemia.
Skin Tests
Corticosteroids may suppress reactions to skin tests.
Toxoids And Live Or Inactivated Vaccines
Due to inhibition of antibody response, patients on prolonged corticosteroid therapy may exhibit a diminished response to toxoids and live or inactivated vaccines. Corticosteroids may also potentiate the replication of some organisms contained in live attenuated vaccines.
Read the entire FDA prescribing information for Triesence (Triamcinolone Acetonide Injectable Suspension)
&Copy; Triesence Patient Information is supplied by Cerner Multum, Inc. and Triesence Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.