Candesartan Cilexetil Hydrochlorothiazide
- Generic Name: candesartan cilexetil hydrochlorothiazide
- Brand Name: Candesartan Cilexetil Hydrochlorothiazide Tablets
Candesartan Cilexetil Hydrochlorothiazide Tablets (candesartan cilexetil hydrochlorothiazide) side effects drug center
Candesartan Cilexetil Hydrochlorothiazide Side Effects Center
Candesartan cilexetil and hydrochlorothiazide tablets are a combination of an antihypertensive drug and a diuretic indicated for the treatment of hypertension, to lower blood pressure. Candesartan cilexetil and hydrochlorothiazide is available in generic form. Common side effects of candesartan cilexetil and hydrochlorothiazide include:
- upper respiratory tract infection,
- back pain,
- flu-like symptoms,
- dizziness,
- cough,
- itching and
- rash.
The usual recommended starting dose of candesartan cilexetil is 16 mg once daily when it is used as monotherapy in patients who are not volume depleted. Candesartan cilexetil tablets can be administered once or twice daily with total daily doses ranging from 8 mg to 32 mg. Hydrochlorothiazide is effective in doses of 12.5 to 50 mg once daily. Candesartan cilexetil and hydrochlorothiazide may interact with nonsteroidal anti-inflammatory drugs (NSAIDs) including selective cyclooxygenase-2 inhibitors (COX-2 inhibitors, angiotensin receptor blockers, ACE inhibitors, aliskiren, potassium sparing diuretics, potassium supplements, potassium-containing salt substitutes, other drugs that raise blood potassium levels, alcohol, barbiturates, narcotics, antidiabetic drugs (oral agents and insulin), diazoxide, cholestyramine, colestipol, muscle relaxants, digitalis, noradrenaline, steroids, adrenocorticotropic hormone (ACTH), cyclophosphamide, methotrexate, and cyclosporine. Tell your doctor all medications and supplements you use. Candesartan cilexetil and hydrochlorothiazide is not recommended for use during pregnancy; it can cause birth defects and fetal death. It is unknown if candesartan passes into breast milk. Hydrochlorothiazide passes into breast milk. Because of the potential for adverse effects on a nursing infant, breastfeeding while using candesartan cilexetil and hydrochlorothiazide is not recommended.
Our Candesartan Cilexetil and Hydrochlorothiazide Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
Candesartan Cilexetil Hydrochlorothiazide Consumer Information
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
In rare cases, hydrochlorothiazide and candesartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.
Also call your doctor at once if you have:
- eye pain, vision problems;
- a light-headed feeling, like you might pass out;
- little or no urinating;
- jaundice (yellowing of the skin or eyes);
- easy bruising, unusual bleeding; or
- signs of an electrolyte imbalance--increased thirst or urination, confusion, vomiting, constipation, muscle pain or weakness, leg cramps, bone pain, lack of energy, irregular heartbeats, tingly feeling.
Common side effects may include:
- dizziness;
- back pain; or
- cold or flu symptoms.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Candesartan Cilexetil Hydrochlorothiazide (candesartan cilexetil hydrochlorothiazide)
Candesartan Cilexetil Hydrochlorothiazide Professional Information
SIDE EFFECTS
Candesartan Cilexetil-Hydrochlorothiazide
Candesartan cilexetil and hydrochlorothiazide tablets have been evaluated for safety in more than 2800 patients treated for hypertension. More than 750 of these patients were studied for at least six months and more than 500 patients were treated for at least one year. Adverse experiences have generally been mild and transient in nature and have only infrequently required discontinuation of therapy. The overall incidence of adverse events reported with candesartan cilexetil and hydrochlorothiazide tablets were comparable to placebo. The overall frequency of adverse experiences was not related to dose, age, gender, or race.
In placebo-controlled trials that included 1089 patients treated with various combinations of candesartan cilexetil (doses of 2 to 32 mg) and hydrochlorothiazide (doses of 6.25 to 25 mg) and 592 patients treated with placebo, adverse events, whether or not attributed to treatment, occurring in greater than 2% of patients treated with candesartan cilexetil and hydrochlorothiazide tablets and that were more frequent for candesartan cilexetil and hydrochlorothiazide tablets than placebo were: Respiratory System Disorder: upper respiratory tract infection (3.6% vs. 3.0%); Body as a Whole: back pain (3.3% vs. 2.4%); influenza-like symptoms (2.5% vs. 1.9%); Central/Peripheral Nervous System: dizziness (2.9% vs. 1.2%).
Post-Marketing Experience
The following have been very rarely reported in post-marketing experience with candesartan cilexetil:
Digestive
Abnormal hepatic function and hepatitis.
Hematologic
Neutropenia, leukopenia, and agranulocytosis.
Immunologic
Metabolic And Nutritional Disorders
Respiratory System Disorders
Cough
Skin And Appendages Disorders
Rare reports of rhabdomyolysis have been reported in patients receiving angiotensin II receptor blockers.
Hydrochlorothiazide
Other adverse experiences that have been reported with hydrochlorothiazide, without regard to causality, are listed below:
Gastrointestinal
Pancreatitis, jaundice (intrahepatic cholestatic jaundice), sialadenitis, cramping, constipation, gastric irritation, anorexia
Hematologic
Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia
Hypersensitivity
Anaphylactic reactions, necrotizing angiitis (vasculitis and cutaneous vasculitis), respiratory distress including pneumonitis and pulmonary edema, photosensitivity, urticaria, purpura
Musculoskeletal
Muscle spasm
Skin
Erythema multiforme including Stevens-Johnson syndrome, exfoliative dermatitis including toxic epidermal necrolysis, alopecia
Special Senses
Transient blurred vision, xanthopsia
Urogenital
Read the entire FDA prescribing information for Candesartan Cilexetil Hydrochlorothiazide (candesartan cilexetil hydrochlorothiazide)
© Candesartan Cilexetil Hydrochlorothiazide Patient Information is supplied by Cerner Multum, Inc. and Candesartan Cilexetil Hydrochlorothiazide Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.