Medical Information Only: This medication is not sold on this site. The information provided is for reference purposes only. Please consult your local physician or pharmacist for treatment.

Aciphex Side Effects Center

Medically reviewed by Min Clinic Staff | Updated: January 2026

Aciphex (Rabeprazole Sodium) side effects drug center

 

PROFESSIONAL

CONSUMER

SIDE EFFECTS

 

Aciphex Side Effects Center

What Is Aciphex?

Aciphex (rabeprazole sodium) is a proton pump inhibitor (PPI) to reduce stomach acid and is used for the treatment of gastroesophageal reflux disease (GERD), duodenal ulcers, and used in combination with antibiotics to treat Helicobacter pylori (H. pylori) bacterial infections in the stomach. Aciphex is available as generic termed rabeprazole sodium.

What Are Side Effects of Aciphex?

Common side effects of Aciphex may include:

  • rash or itching,
  • upset stomach, diarrhea, or gas,
  • sore throat,
  • headache,
  • insomnia, or
  • nervousness.

Serious side effects of Aciphex include:

  • hepatitis or abnormal brain function/structure (encephalopathy);
  • severe stomach pain or bloody diarrhea;
  • sudden pain or difficulty moving the hip, wrist, or back;
  • seizures (convulsions);
  • urinating less than usual or blood in the urine;
  • swelling, rapid weight gain, or joint and muscle pains;
  • skin rash on cheeks or arms made worse by sunlight;
  • dizziness, fast/irregular heart rate, or tremors;
  • muscle cramps or spasms in your hands or feet;
  • cough, difficulty swallowing, or choking; and
  • unusual bleeding (nosebleeds, gums, or heavy menstrual flow) and bloody or tarry stools.

Get medical help right away if you have any of the symptoms listed above.

Dosage for Aciphex

Aciphex is available in 20 mg strength enteric-coated tablets. The usual dose of Aciphex is one 20 mg tablet per day for 4 to 8 weeks.

What Drugs, Substances, or Supplements Interact with Aciphex?

Aciphex may interact with atazanavir, blood thinners, digoxin, diuretics (water pills), ketoconazole, methotrexate, or cyclosporine. Tell your doctor all medications and supplements you use.

Aciphex During Pregnancy and Breastfeeding

Pregnant women and their doctors need to balance the need vs. the potential problems of Aciphex in pregnancy and breastfeeding. Aciphex has been used in pediatric patients aged 12 and above for GERD treatment; no studies under age 12 are available.