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Protonix vs. Nexium

What Drugs Interact With Protonix?

Protonix may interact with atazanavir, blood thinners, digoxin, diuretics (water pills), ketoconazole, or methotrexate.

Protonix may also interact with nelfinavir, ampicillin, or iron.

What Drugs Interact With Nexium?

Nexium may interact with atazanavir, nelfinavir, digoxin, or methotrexate.

Nexium may also interact with cilostazol, citalopram, clopidogrel, dexamethasone, diazepam, rifampin, St. John's wort, tacrolimus, voriconazole, or HIV/AIDS medications.

How Should Protonix Be Taken?

The recommended adult dose of Protonix is 40 mg once daily.

  • Protonix Oral Suspension should be taken 30 minutes before a meal
  • Protonix Oral Suspension should only be taken with applesauce or apple juice 30 minutes before a meal.
  • Protonix Oral Suspension should not be taken in or with water or other liquids, or with other foods.
  • Protonix Oral Suspension should not be chewed or crushed.
  • Protonix Oral Suspension packet should not be divided to make a smaller dose.

How Should Nexium Be Taken?

  • Take Nexium exactly as prescribed by your doctor.
  • Do not change your dose or stop Nexium without talking to your doctor.
  • Take Nexium at least 1 hour before a meal.
  • Swallow Nexium capsules whole. Never chew or crush Nexium.
  • If you have difficulty swallowing Nexium capsules, you may open the capsule and empty the contents into a tablespoon of applesauce. Do not crush or chew the granules. Be sure to swallow the applesauce right away. Do not store it for later use.
  • If you forget to take a dose of Nexium, take it as soon as you remember. If it is almost time for your next dose, do not take the missed dose. Take the next dose on time. Do not take a double dose to make up for a missed dose.
  • If you take too much Nexium, call your doctor or local poison control center right away, or go to the nearest hospital emergency room.
  • See the “Instructions for Use” at the end of this Medication Guide for instructions how to take Nexium For Delayed-Release Oral Suspension, and how to mix and give Nexium Delayed- Release Capsules and Nexium For Delayed-Release Oral Suspension, through a nasogastric tube or gastric tube.
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