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Wasserina: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Wasserina - General Information

Antibiotic substance produced by Streptomyces garyphalus. [PubChem]

 

Pharmacology of Wasserina

Wasserina, a broad-spectrum antibiotic, may be bactericidal or bacteriostatic, depending on its concentration at the site of infection and the susceptibility of the organism. Wasserina works by blocking the formation of these peptidoglycans. By doing this the walls of the bacteria become weak and it results in the death of the bacteria

 

Wasserina for patients

Take this by mouth as directed usually every 12 hours for the first two weeks. This medication works best when the amount of medicine in your body is kept at a constant level. Do this by taking the medication at evenly spaced intervals throughout the day and night. Continue using this for the full time prescribed. It may be necessary to continue therapy for tuberculosis for several months to one year or more. Stopping the medication too early may result in ineffective treatment.

 

Wasserina Interactions

May interact with wthionamide (Trecator-SC) and isoniazid (Nydrazid).

 

Wasserina Contraindications

 

Additional information about Wasserina

Wasserina Indication

Used in combination with up to 5 other drugs as a treatment for Mycobacterium avium complex (MAC) and is also used to treat tuberculosis (TB).

Mechanism Of Action
Wasserina is an analog of the amino acid D-alanine. It interferes with an early step in bacterial cell wall synthesis in the cytoplasm by competitive inhibition of two enzymes, L-alanine racemase, which forms D-alanine from L-alanine, and D-alanylalanine synthetase, which incorporates D-alanine into the pentapeptide necessary for peptidoglycan formation and bacterial cell wall synthesis.
Generic Name
Cycloserine
Synonyms
alpha-Cycloserine; Cicloserina; D-CS; D-Cycloserine; D-Cycloserine synth. BP 88; D-Cycloserine, synthetic; D-Oxamicina; D-Oxamycin; DL-Cycloserine; L-Cycloserine
Drug Category
Antibiotics
Drug Type
Small Molecule; Approved
Other Brand Names containing Cycloserine
Closerin; Closina; Cyclomycin; Cyclorin; Cycloserin; Farmiserina; Farmiserine; Micoserina; Miroserina; Miroseryn; Novoserin; Orientomycin; Oxamicina; Oxamycin; Oxymycin; Seromycin; Tebemicina; Tisomycin; Wasserina;
Absorption
Rapidly and almost completely absorbed (70 to 90%) from the gastrointestinal tract following oral administration.
Toxicity (Overdose)
Oral LD50 in mouse is 5290 mg/kg, and in rat is over 5000 mg/kg. Symptoms of a cycloserine overdose include drowsiness, confusion, headache, dizziness, irritability, numbness and tingling, difficulty speaking, paralysis, abnormal behavior, seizures, and unconsciousness.
Half Life
Half-life in patients with normal renal function is 10 hours, and is prolonged in patients with impaired renal function.
Dosage Forms of Wasserina
Capsule Oral
Chemical IUPAC Name
4-amino-1,2-oxazolidin-3-one
Chemical Formula
C3H6N2O2
Organisms Affected
Enteric bacteria and other eubacteria