Tisomycin
Tisomycin - General Information
Antibiotic substance produced by Streptomyces garyphalus. [PubChem]
Pharmacology of Tisomycin
Tisomycin, a broad-spectrum antibiotic, may be bactericidal or bacteriostatic, depending on its concentration at the site of infection and the susceptibility of the organism. Tisomycin works by blocking the formation of these peptidoglycans. By doing this the walls of the bacteria become weak and it results in the death of the bacteria
Tisomycin for patients
Take this by mouth as directed usually every 12 hours for the first two weeks. This medication works best when the amount of medicine in your body is kept at a constant level. Do this by taking the medication at evenly spaced intervals throughout the day and night. Continue using this for the full time prescribed. It may be necessary to continue therapy for tuberculosis for several months to one year or more. Stopping the medication too early may result in ineffective treatment.
Tisomycin Interactions
May interact with wthionamide (Trecator-SC) and isoniazid (Nydrazid).
Tisomycin Contraindications
Additional information about Tisomycin
Tisomycin Indication: Used in combination with up to 5 other drugs as a treatment for Mycobacterium avium complex (MAC) and is also used to treat tuberculosis (TB).
Mechanism Of Action: Tisomycin is an analog of the amino acid D-alanine. It interferes with an early step in bacterial cell wall synthesis in the cytoplasm by competitive inhibition of two enzymes, L-alanine racemase, which forms D-alanine from L-alanine, and D-alanylalanine synthetase, which incorporates D-alanine into the pentapeptide necessary for peptidoglycan formation and bacterial cell wall synthesis.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Cycloserine
Synonyms: alpha-Cycloserine; Cicloserina; D-CS; D-Cycloserine; D-Cycloserine synth. BP 88; D-Cycloserine, synthetic; D-Oxamicina; D-Oxamycin; DL-Cycloserine; L-Cycloserine
Drug Category: Antibiotics
Drug Type: Small Molecule; Approved
Other Brand Names containing Cycloserine: Closerin; Closina; Cyclomycin; Cyclorin; Cycloserin; Farmiserina; Farmiserine; Micoserina; Miroserina; Miroseryn; Novoserin; Orientomycin; Oxamicina; Oxamycin; Oxymycin; Seromycin; Tebemicina; Tisomycin; Wasserina;
Absorption: Rapidly and almost completely absorbed (70 to 90%) from the gastrointestinal tract following oral administration.
Toxicity (Overdose): Oral LD50 in mouse is 5290 mg/kg, and in rat is over 5000 mg/kg. Symptoms of a cycloserine overdose include drowsiness, confusion, headache, dizziness, irritability, numbness and tingling, difficulty speaking, paralysis, abnormal behavior, seizures, and unconsciousness.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Half-life in patients with normal renal function is 10 hours, and is prolonged in patients with impaired renal function.
Dosage Forms of Tisomycin: Capsule Oral
Chemical IUPAC Name: 4-amino-1,2-oxazolidin-3-one
Chemical Formula: C3H6N2O2
Cycloserine on Wikipedia: https://en.wikipedia.org/wiki/Cycloserine
Organisms Affected: Enteric bacteria and other eubacteria