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Supotran: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Supotran - General Information

A non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm. [PubChem]

 

Pharmacology of Supotran

Supotran is a non-benzodiazepine muscle relaxant. It was discontinued worldwide in 1996 by its manufacturer due to confirmed serious and rare cutaneous reactions (toxic epidermal necrolysis).

 

Additional information about Supotran

Supotran Indication

Used in the management of anxiety and in the treatment of muscle spasm.

Mechanism Of Action
Supotran binds to central benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways.
Generic Name
Chlormezanone
Synonyms
Chlormezanone [BAN-INN-JAN]; Chlormezanon; Chlormezanonum [INN-Latin]; Chlormethazanone; Chlormethazone; Clormetazanone; Clormetazon; Clormezanona [INN-Spanish]; Clormezanone [DCIT]; Dichloromethazanone; Dichloromezanone; dl-Chlormezanone
Drug Category
Antipsychotics; Anti-anxiety Agents; Benzodiazepines; Muscle Relaxants, Central
Drug Type
Small Molecule; Approved; Withdrawn
Other Brand Names containing Chlormezanone
Alinam; Banabil-sintyal; Banabin; Banabin-Sintyal; Banabin-syntyal; Bisina; Chlomedinon; Clorilax; Lobak; Mio-Sed; Miorilax; Muskel; Muskel-Trancopal; Myolespen; Phenarol; Rexan; Rilansyl; Rilaquil; Rilasol; Rilassol; Rilax; Rillasol; Supotran; Suprotan; Tanafol; Trancopal; Trancote; Tranrilax; Transanate;
Toxicity (Overdose)
Symptoms of overdose include drowsiness, weakness, nausea, dizziness, abdominal pain, cerebral oedema and renal tubular necrosis, hyperglycaemia and hypoglycaemia, liver damage, encephalopathy, coma and death.
Chemical IUPAC Name
2-(4-chlorophenyl)-3-methyl-1,1-dioxo-1,3-thiazinan-4-one
Chemical Formula
C11H12ClNO3S
Organisms Affected
Humans and other mammals