Medical Information Only: This medication is not sold on this site. The information provided is for reference purposes only. Please consult your local physician or pharmacist for treatment.

Rexan: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Rexan - General Information

A non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm. [PubChem]

 

Pharmacology of Rexan

Rexan is a non-benzodiazepine muscle relaxant. It was discontinued worldwide in 1996 by its manufacturer due to confirmed serious and rare cutaneous reactions (toxic epidermal necrolysis).

 

Additional information about Rexan

Rexan Indication

Used in the management of anxiety and in the treatment of muscle spasm.

Mechanism Of Action
Rexan binds to central benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways.
Generic Name
Chlormezanone
Synonyms
Chlormezanone [BAN-INN-JAN]; Chlormezanon; Chlormezanonum [INN-Latin]; Chlormethazanone; Chlormethazone; Clormetazanone; Clormetazon; Clormezanona [INN-Spanish]; Clormezanone [DCIT]; Dichloromethazanone; Dichloromezanone; dl-Chlormezanone
Drug Category
Antipsychotics; Anti-anxiety Agents; Benzodiazepines; Muscle Relaxants, Central
Drug Type
Small Molecule; Approved; Withdrawn
Other Brand Names containing Chlormezanone
Alinam; Banabil-sintyal; Banabin; Banabin-Sintyal; Banabin-syntyal; Bisina; Chlomedinon; Clorilax; Lobak; Mio-Sed; Miorilax; Muskel; Muskel-Trancopal; Myolespen; Phenarol; Rexan; Rilansyl; Rilaquil; Rilasol; Rilassol; Rilax; Rillasol; Supotran; Suprotan; Tanafol; Trancopal; Trancote; Tranrilax; Transanate;
Toxicity (Overdose)
Symptoms of overdose include drowsiness, weakness, nausea, dizziness, abdominal pain, cerebral oedema and renal tubular necrosis, hyperglycaemia and hypoglycaemia, liver damage, encephalopathy, coma and death.
Chemical IUPAC Name
2-(4-chlorophenyl)-3-methyl-1,1-dioxo-1,3-thiazinan-4-one
Chemical Formula
C11H12ClNO3S
Organisms Affected
Humans and other mammals