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Neoquess: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Neoquess - General Information

Neoquess is a chemical compound, a tropane alkaloid it is the levo-isomer to atropine. It is a secondary metabolite of some plants, particularly henbane (Hyoscamus niger.)
Neoquess is used to provide symptomatic relief to various gastrointestinal disorders including spasms, peptic ulcers, irritable bowel syndrome, pancreatitis, colic and cystitis. It has also been used to relieve some heart problems, control some of the symptoms of Parkinson's disease, as well as for control of respiratory secretions in end of life care.

 

Pharmacology of Neoquess

L-Neoquess, the active optical isomer of atropine (dl-hyoscyamine), is a tertiary amine anticholinergic gastrointestinal agent.

 

Neoquess for patients

Like other anticholinergic agents, LEVSIN may produce drowsiness, dizziness, or blurred vision. In this event, the patient should be warned not to engage in activities requiring mental alertness such as operating a motor vehicle or other machinery or to perform hazardous work while taking this drug.

Use of LEVSIN may decrease sweating resulting in heat prostration, fever or heat stroke; febrile patients or those who may be exposed to elevated environmental temperatures should use caution.

 

Neoquess Interactions

Additive adverse effects resulting from cholinergic blockade may occur when LEVSIN is administered concomitantly with other antimuscarinics, amantadine, haloperidol, phenothiazines, monoamine oxidase (MAO) inhibitors, tricyclic antidepressants or some antihistamines. Antacids may interfere with the absorption of LEVSIN. Administer LEVSIN before meals; antacids after meals.

 

Neoquess Contraindications

Glaucoma; obstructive uropathy (for example, bladder neck obstruction due to prostatic hypertrophy); obstructive disease of the gastrointestinal tract (as in achalasia, pyloroduodenal stenosis); paralytic ileus, intestinal atony of elderly or debilitated patients; unstable cardiovascular status in acute hemorrhage; severe ulcerative colitis; toxic egacolon complicating ulcerative colitis; myasthenia gravis.

 

Additional information about Neoquess

Neoquess Indication

For treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, irritable bowel syndrome, cystitis, and pancreatitis. Also used to treat certain heart conditions, to control the symptoms of Parkinson's disease and rhinitis.

Mechanism Of Action
Neoquess competes favorably with acetylcholine for binding at muscarinic receptors in the salivary, bronchial, and sweat glands as well as in the eye, heart, and gastrointestinal tract. The actions of hyoscyamine result in a reduction in salivary, bronchial, gastric and sweat gland secretions, mydriasis, cycloplegia, change in heart rate, contraction of the bladder detrusor muscle and of the gastrointestinal smooth muscle, and decreased gastrointestinal motility.
Drug Interactions
Donepezil Possible antagonism of action
Food Interactions
Take 30 minutes before meals, and at bedtime.
Generic Name
Hyoscyamine
Synonyms
L-Tropine Tropate; L-Hyoscyamine; L-Hyoscamine; L-Hyopscyamine; L-Atropine; Hyocyamine
Drug Category
Antiarrhythmic Agents; Antimuscarinics; Antispasmodics; Bronchodilator Agents; Mydriatics
Drug Type
Small Molecule; Approved
Other Brand Names containing Hyoscyamine
Anaspaz; Cystospaz; Daturine; Duboisine; Duretter; Egacene; Egazil; Gastrosed; Levbid; Levsin; Levsinex; OIN; Peptard; Scopolia Extract; Symax; Buwecon; Donnamar; NuLev; Neoquess;
Absorption
Absorbed totally and completely by sublingual administration as well as oral administration.
Toxicity (Overdose)
Symptoms of overdose include headache, nausea, vomiting, blurred vision, dilated pupils, hot dry skin, dizziness, dryness of the mouth, difficulty in swallowing, and CNS stimulation. LD50=mg/kg(orally in rat)
Protein Binding
50%
Biotransformation
Hepatic
Half Life
2-3.5 hours
Dosage Forms of Neoquess
Solution / drops Oral
Chemical IUPAC Name
(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) (2S)-3-hydroxy-2-phenylpropanoate
Chemical Formula
C17H23NO3
Organisms Affected
Humans and other mammals