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Largactil Liquid: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Largactil Liquid - General Information

The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine&

 

Pharmacology of Largactil Liquid

Largactil Liquid is a psychotropic agent indicated for the treatment of schizophrenia. It also exerts sedative and antiemetic activity. Largactil Liquid has actions at all levels of the central nervous system-primarily at subcortical levels-as well as on multiple organ systems. Largactil Liquid has strong antiadrenergic and weaker peripheral anticholinergic activity; ganglionic blocking action is relatively slight. It also possesses slight antihistaminic and antiserotonin activity.

 

Largactil Liquid for patients

PATIENT INFORMATION Please follow the link below for more information and the links in Drug_reference region in DrugBank. https://www.rxlist.com/cgi/generic3/chlorpromazine_wcp.htm

 

Largactil Liquid Interactions

The concurrent use of two or more drugs with anticholinergic activity--such as an antipsychotic drug (eg, chlorpromazine), an antiparkinsonian drug (eg, trihexyphenidyl), and/or a tricyclic antidepressant (eg, amitriptyline)--commonly results in excessive anticholinergic effects, including dry mouth and associated dental complications, blurred vision, and, in patients exposed to high temperature and humidity, hyperpyrexia.

Interactions may also occur with the following: anti-depressants/anti-anxiety drugs, drugs used to treat an overactive thyroid, beta-blockers (e.g., propranolol), sparfloxacin, grepafloxacin, guanethidine, guanadrel, metrizamide, cabergoline, lithium, narcotic pain medication (e.g., codeine), drugs used to aid sleep, drowsiness-causing antihistamines (e.g., diphenhydramine), any other drugs that may make you drowsy.

 

Largactil Liquid Contraindications

Do not use in patients with known hypersensitivity to phenothiazines. Do not use in comatose states or in the presence of large amounts of central nervous system depressants (alcohol, barbiturates, narcotics, etc.).

 

Additional information about Largactil Liquid

Largactil Liquid Indication

For the treatment of schizophrenia, control nausea and vomiting, For relief of restlessness and apprehension before surgery, adjunct in the treatment of tetanus, control the manifestations of the manic type of manic-depressive illness.

Mechanism Of Action
Largactil Liquid acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects).
Drug Interactions
Amphetamine Decreased anorexic effect, may increase psychotic symptoms
Food Interactions
Take with food to reduce irritation.
Generic Name
Chlorpromazine
Drug Category
Antipsychotics; Antiemetics; Dopamine Antagonists; Phenothiazines
Drug Type
Small Molecule; Approved
Other Brand Names containing Chlorpromazine
Chlorpromanyl-20; Chlorpromanyl-40; Chlorpromazine Hydrochloride Intensol; Largactil Liquid; Largactil Oral Drops; Novo-Chlorpromazine; Thorazine Spansule;
Toxicity (Overdose)
Agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, restlessness
Protein Binding
40%
Dosage Forms of Largactil Liquid
Tablet Oral
Chemical IUPAC Name
3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
Chemical Formula
C17H19ClN2S
Organisms Affected
Humans and other mammals