Medical Information Only: This medication is not sold on this site. The information provided is for reference purposes only. Please consult your local physician or pharmacist for treatment.

Issium: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Issium - General Information

Issium is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.

 

Pharmacology of Issium

Issium is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity.

 

Additional information about Issium

Issium Indication

Used in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.

Food Interactions
Take without regard to meals.
Generic Name
Flunarizine
Synonyms
Flunarizinum [inn-latin]; Flunarizina [inn-spanish]; 1-(Bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine; (E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine; Flunarizine Hydrochloride; flunarizine dihydrochloride
Drug Category
Anticonvulsants; Calcium Channel Blockers; Histamine H1 Antagonists; Vasodilator Agents
Drug Type
Small Molecule; Approved
Other Brand Names containing Flunarizine
Sibelium; Novo-Flunarizine; Apo-flunarizine capsules; Vertix; Zinasen; Issium; Fluvert; Flufenal;
Absorption
85% following oral administration.
Protein Binding
99% bound to plasma proteins
Biotransformation
Hepatic, to two metabolites via N-dealylation and hydroxylation.
Half Life
18 days
Dosage Forms of Issium
Capsule Oral
Chemical IUPAC Name
1-[bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine
Chemical Formula
C26H26F2N2
Organisms Affected
Humans and other mammals