Dosing and uses of Yodoxin (iodoquinol)
Adult dosage forms and strengths
tablets
- 210mg
- 650mg
Intestinal Amebiasis
650 mg PO PC TID for 20 days
Other Indications & Uses
Entamoeba histolytica
Off-label: balantidiasis, Blastocystis hominis, Dientamoeba fragilis
Pediatric dosage forms and strengths
tablets
- 210mg
- 650mg
Intestinal Amebiasis
30-40 mg/kg/day divided PO PC TID PO for 20 days; not to exceed 1.95 g/day
Yodoxin (iodoquinol) adverse (side) effects
Frequency not defined
Fever
Chills
Agitation
Retrograde amnesia
Headache
Rash
Urticaria
Pruritus
Thyroid gland enlargement
Diarrhea
Nausea
Vomiting
Stomach pain
Abdominal cramps
Peripheral neuropathy
Weakness
Optic neuritis
Optic atrophy
Visual impairment
Itching of rectal area
Warnings
Contraindications
Hypersensitivity to 8-hydroxyquinolones or iodoquinoL
Iodine sensitivity
Cautions
Thyroid dz
Interferes w/ thyroid tests for up to 6 mth after discontiunation
Do not repeat course before 2-3 wk
Not effective in amebic hepatitis or liver abscess
Pregnancy and lactation
Pregnancy category: C
Lactation: unknown
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Yodoxin (iodoquinol)
Absorption: poor & erratic
Metabolism: hepatic
Excretion: mostly feces; metabolites in urine
Mechanism of action
Acts primarily in intestinal lumen
