OxyContin
- Generic Name: oxycodone hcl
- Brand Name: Oxycontin
- Drug Class: Opioid Agonists
Oxycontin (Oxycodone HCl) side effects drug center
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OxyContin Side Effects Center
What Is OxyContin?
OxyContin (oxycodone hydrochloride) is an opioid drug used for the management of moderate to severe pain, usually for an extended time period. Oxycontin is not an "as needed for pain (PRN) drug." Oxycontin is available as a generic drug.
What Are Side Effects of OxyContin?
Common side effects of Oxycontin include
- constipation,
- nausea,
- stomach pain,
- loss of appetite,
- vomiting,
- sleepiness,
- tiredness,
- drowsiness,
- dizziness,
- lightheadedness,
- weakness,
- itching,
- headache,
- dry mouth,
- sweating, and
- decreases in the ability to feel pain.
Tell your doctor if you experience serious side effects of Oxycontin including
- respiratory depression,
- apnea (stopped breathing),
- respiratory arrest,
- circulatory depression,
- hypotension (low blood pressure),
- shock, and
- death.
Dosage for OxyContin
Oxycontin (oxycodone hydrochloride) is available as controlled-release tablets in strengths of 10, 15, 20, 30, 40, 60, 80, and 160 mg tablets (60 mg and above used only for opioid tolerant patients). The tablets must be swallowed whole because broken or chewed tablets release the drug too rapidly and because Oxycontin is rapidly adsorbed, too concentrated levels will be present in the body which can lead to death.
What Drugs, Substances, or Supplements Interact with OxyContin?
Oxycontin may interact with other narcotic pain medications, sedatives, tranquilizers, sleeping pills, muscle relaxers, other medicines that can make you sleepy or slow your breathing, pentazocine, nalbuphine, butorphanol, or buprenorphine. Tell your doctor all medications and supplements you use. This opioid is often the drug of choice for addictive use and can easily lead to dependency. Some patients may develop tolerance for Oxycontin and need to be slowly weaned off the drug.
OxyContin During Pregnancy and Breastfeeding
Safety has not been established in children under age 18; caution or avoidance is suggested in pregnant and breastfeeding women as infants can be born with opioid tolerance and depressed respirations. In addition, low concentrations of Oxycontin have been found in breast milk.
Additional Information
Our Oxycontin Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
OxyContin Consumer Information
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should give naloxone and/or seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.
Call your doctor at once if you have:
- noisy breathing, sighing, shallow breathing, breathing that stops during sleep;
- a slow heart rate or weak pulse;
- a light-headed feeling, like you might pass out;
- confusion, unusual thoughts or behavior;
- seizure (convulsions);
- low cortisol levels-- nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness; or
- high levels of serotonin in the body--agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea.
Serious breathing problems may be more likely in older adults and in those who are debilitated or have wasting syndrome or chronic breathing disorders.
Common side effects may include:
- drowsiness, headache, dizziness, tiredness; or
- constipation, stomach pain, nausea, vomiting.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for OxyContin (Oxycodone HCl)
OxyContin Professional Information
SIDE EFFECTS
The following serious adverse reactions are described elsewhere in the labeling:
- Addiction, Abuse, and Misuse [see WARNINGS AND PRECAUTIONS]
- Life-Threatening Respiratory Depression [see WARNINGS AND PRECAUTIONS]
- Neonatal Opioid Withdrawal Syndrome [see WARNINGS AND PRECAUTIONS]
- Interactions With Benzodiazepines and Other CNS Depressants [see WARNINGS AND PRECAUTIONS]
- Adrenal Insufficiency [see WARNINGS AND PRECAUTIONS]
- Severe Hypotension [see WARNINGS AND PRECAUTIONS]
- Gastrointestinal Adverse Reactions [see WARNINGS AND PRECAUTIONS]
- Seizures [see WARNINGS AND PRECAUTIONS]
- Withdrawal [see WARNINGS AND PRECAUTIONS]
Clinical Trial Experience
Adult Clinical Trial Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
The safety of OXYCONTIN was evaluated in double-blind clinical trials involving 713 patients with moderate to severe pain of various etiologies. In open-label studies of cancer pain, 187 patients received OXYCONTIN in total daily doses ranging from 20 mg to 640 mg per day. The average total daily dose was approximately 105 mg per day.
OXYCONTIN may increase the risk of serious adverse reactions such as those observed with other opioid analgesics, including respiratory depression, apnea, respiratory arrest, circulatory depression, hypotension, or shock [see OVERDOSE].
The most common adverse reactions (>5%) reported by patients in clinical trials comparing OXYCONTIN with placebo are shown in Table 2 below:
TABLE 2: Common Adverse Reactions (>5%)
Adverse Reaction | OXYCONTIN (n=227) |
Placebo (n=45) |
(%) | (%) | |
Constipation | (23) | (7) |
Nausea | (23) | (11) |
Somnolence | (23) | (4) |
Dizziness | (13) | (9) |
Pruritus | (13) | (2) |
Vomiting | (12) | (7) |
Headache | (7) | (7) |
Dry Mouth | (6) | (2) |
Asthenia | (6) | - |
Sweating | (5) | (2) |
In clinical trials, the following adverse reactions were reported in patients treated with OXYCONTIN with an incidence between 1% and 5%:
Gastrointestinal disorders: abdominal pain, diarrhea, dyspepsia, gastritis
General disorders and administration site conditions: chills, fever
Metabolism and nutrition disorders: anorexia
Musculoskeletal and connective tissue disorders: twitching
Psychiatric disorders: abnormal dreams, anxiety, confusion, dysphoria, euphoria, insomnia, nervousness, thought abnormalities
Respiratory, thoracic and mediastinal disorders: dyspnea, hiccups
Skin and subcutaneous tissue disorders: rash
Vascular disorders: postural hypotension
The following adverse reactions occurred in less than 1% of patients involved in clinical trials:
Blood and lymphatic system disorders: lymphadenopathy
Ear and labyrinth disorders: tinnitus
Eye disorders: abnormal vision
Gastrointestinal disorders: dysphagia, eructation, flatulence, gastrointestinal disorder, increased appetite, stomatitis
General disorders and administration site conditions: withdrawal syndrome (with and without seizures), edema, peripheral edema, thirst, malaise, chest pain, facial edema
Injury, poisoning and procedural complications: accidental injury
Investigations: ST depression
Metabolism and nutrition disorders: dehydration
Nervous system disorders: syncope, migraine, abnormal gait, amnesia, hyperkinesia, hypoesthesia, hypotonia, paresthesia, speech disorder, stupor, tremor, vertigo, taste perversion
Psychiatric disorders: depression, agitation, depersonalization, emotional lability, hallucination
Renal and urinary disorders: dysuria, hematuria, polyuria, urinary retention
Reproductive system and breast disorders: impotence
Respiratory, thoracic and mediastinal disorders: cough increased, voice alteration
Skin and subcutaneous tissue disorders: dry skin, exfoliative dermatitis
Clinical Trial Experience In Pediatric Patients 11 Years And Older
The safety of OXYCONTIN has been evaluated in one clinical trial with 140 patients 11 to 16 years of age. The median duration of treatment was approximately three weeks. The most frequently reported adverse events were vomiting, nausea, headache, pyrexia, and constipation.
Table 3 includes a summary of the incidence of treatment emergent adverse events reported in ≥5% of patients.
Table 3: Incidence of Adverse Reactions Reported in ≥ 5.0% Patients 11 to 16 Years
System Organ Class Preferred Term |
11 to 16 Years (N=140) n (%) |
Any Adverse Event >= 5% | 71 (51) |
GASTROINTESTINAL DISORDERS | 56 (40) |
Vomiting | 30 (21) |
Nausea | 21 (15) |
Constipation | 13 (9) |
Diarrhea | 8 (6) |
GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS | 32 (23) |
Pyrexia | 15 (11) |
METABOLISM AND NUTRITION DISORDERS | 9 (6) |
Decreased appetite | 7 (5) |
NERVOUS SYSTEM DISORDERS | 37 (26) |
Headache | 20 (14) |
Dizziness | 12 (9) |
SKIN AND SUBCUTANEOUS TISSUE DISORDERS | 23 (16) |
Pruritus | 8 (6) |
The following adverse reactions occurred in a clinical trial of OXYCONTIN in patients 11 to 16 years of age with an incidence between ≥1.0% and < 5.0%. Events are listed within each System/Organ Class.
Blood and lymphatic system disorders: febrile neutropenia, neutropenia
Cardiac disorders: tachycardia
Gastrointestinal disorders: abdominal pain, gastroesophageal reflux disease
General disorders and administration site conditions: fatigue, pain, chills, asthenia
Injury, poisoning, and procedural complications: procedural pain, seroma
Investigations: oxygen saturation decreased, alanine aminotransferase increased, hemoglobin decreased, platelet count decreased, neutrophil count decreased, red blood cell count decreased, weight decreased
Metabolic and nutrition disorders: hypochloremia, hyponatremia
Musculoskeletal and connective tissue disorders: pain in extremity, musculoskeletal pain
Nervous system disorders: somnolence, hypoesthesia, lethargy, paresthesia
Psychiatric disorders: insomnia, anxiety, depression, agitation
Renal and urinary disorders: dysuria, urinary retention
Respiratory, thoracic, and mediastinal disorders: oropharyngeal pain
Skin and subcutaneous tissue disorders: hyperhidrosis, rash
Postmarketing Experience
The following adverse reactions have been identified during post-approval use of extendedrelease oxycodone. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Abuse, addiction, aggression, amenorrhea, cholestasis, completed suicide, death, dental caries, increased hepatic enzymes, hyperalgesia, hypogonadism, hyponatremia, ileus, intentional overdose, mood altered, muscular hypertonia, overdose, palpitations (in the context of withdrawal), seizures, suicidal attempt, suicidal ideation, syndrome of inappropriate antidiuretic hormone secretion, and urticaria.
In addition to the events listed above, the following have also been reported, potentially due to the swelling and hydrogelling property of the tablet: choking, gagging, regurgitation, tablets stuck in the throat and difficulty swallowing the tablet.
Serotonin Syndrome
Cases of serotonin syndrome, a potentially life-threatening condition, have been reported during concomitant use of opioids with serotonergic drugs.
Adrenal Insufficiency
Cases of adrenal insufficiency have been reported with opioid use, more often following greater than one month of use.
Anaphylaxis
Anaphylaxis has been reported with ingredients contained in OXYCONTIN.
Androgen Deficiency
Cases of androgen deficiency have occurred with chronic use of opioids [see CLINICAL PHARMACOLOGY].
Read the entire FDA prescribing information for OxyContin (Oxycodone HCl)
&Copy; OxyContin Patient Information is supplied by Cerner Multum, Inc. and OxyContin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.