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Odefsey Side Effects Center

Medically reviewed by Min Clinic Staff | Updated: January 2026
  • Generic Name: emtricitabine, rilpivirine, and tenofovir alafenamide fixed-dose combination tablets
  • Brand Name: Odefsey

Odefsey (Emtricitabine, Rilpivirine, and Tenofovir Alafenamide Fixed-dose Combination Tablets) side effects drug center

 

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CONSUMER

SIDE EFFECTS

 

Odefsey Side Effects Center

What Is Odefsey?

Odefsey (emtricitabine, rilpivirine, and tenofovir alafenamide) is a combination of two HIV nucleoside analog reverse transcriptase inhibitors (NRTIs) and a non-nucleoside reverse transcriptase inhibitor (NNRTI) indicated as a complete regimen for the treatment of HIV-1 infection in patients 12 years of age and older as initial therapy in those with no antiretroviral treatment history with HIV-1 RNA less than or equal to 100,000 copies per mL; or to replace a stable antiretroviral regimen in those who are virologically-suppressed (HIV-1 RNA less than 50 copies per mL) for at least six months with no history of treatment failure and no known substitutions associated with resistance to the individual components of Odefsey.

What Are Side Effects of Odefsey?

Common side effects of Odefsey include:

  • depressive disorders (depressed mood, depression, general unease, mood changes, negative thoughts, suicide attempts, suicidal ideation),
  • insomnia,
  • headache,
  • nausea,
  • drowsiness,
  • dizziness,
  • abdomincal pain,
  • rash,