Biorphen
- Generic Name: phenylephrine hydrochloride injection
- Brand Name: Biorphen
Biorphen (Phenylephrine Hydrochloride Injection ) side effects drug center
Biorphen Side Effects Center
What Is Biorphen?
Biorphen (phenylephrine hydrochloride) is an alpha-1 adrenergic receptor agonist used to treat clinically important low blood pressure (hypotension) resulting primarily from vasodilation in the setting of anesthesia.
What Are Side Effects of Biorphen?
Side effects of Biorphen include:
- nausea,
- vomiting, and
- headache
Dosage for Biorphen
Dosing of Biorphen for treatment of hypotension during anesthesia is given as a bolus intravenous injection of 40 mcg to 100 mcg every 1-2 minutes as needed, not to exceed 200 mcg.
Biorphen In Children
Safety and effectiveness of Biorphen in pediatric patients has not been established.
What Drugs, Substances, or Supplements Interact with Biorphen?
Biorphen may interact with other medicines such as:
- monoamine oxidase inhibitors (MAOI),
- oxytocin and oxytocic drugs,
- tricyclic antidepressants,
- angiotensin ,
- aldosterone,
- atropine,
- steroids,
- norepinephrine transporter inhibitors,
- ergot alkaloids,
- alpha-blockers,
- phosphodiesterase Type 5 inhibitors,
- mixed alpha- and beta-receptor antagonists,
- calcium channel blockers,
- benzodiazepines,
- ACE inhibitors, and
- centrally acting sympatholytic agents
Tell your doctor all medications and supplements you use.
Biorphen During Pregnancy and Breastfeeding
Tell your doctor if you are pregnant or plan to become pregnant before using Biorphen; it is unknown how it would affect a fetus It is unknown if Biorphen passes into breast milk. Consult your doctor before breastfeeding.
Additional Information
Our Biorphen (phenylephrine hydrochloride) Injection, for Intravenous Use Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Biorphen Professional Information
SIDE EFFECTS
Adverse reactions to BIORPHEN are primarily attributable to excessive pharmacologic activity. Adverse reactions reported in published clinical studies, observational trials, and case reports of BIORPHEN are listed below by body system. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency reliably or to establish a causal relationship to drug exposure.
Cardiac disorders: Reflex bradycardia, lowered cardiac output, ischemia, hypertension, arrhythmias
Gastrointestinal disorders: Epigastric pain, vomiting, nausea
Nervous system disorders: Headache, blurred vision, neck pain, tremors
Vascular disorders: Hypertensive crisis
Respiratory, Thoracic and Mediastinal Disorders: Dyspnea
Skin and subcutaneous tissue disorders: Pruritis
DRUG INTERACTIONS
Interactions That Augment Pressor Effect
The increasing blood pressure effect of BIORPHEN is increased in patients receiving:
- Monoamine oxidase inhibitors (MAOI)
- Oxytocin and oxytocic drugs
- Tricyclic antidepressants
- Angiotensin, aldosterone
- Atropine
- Steroids, such as hydrocortisone
- Norepinephrine transporter inhibitors, such as atomoxetine
- Ergot alkaloids, such as methylergonovine maleate
Interactions That Antagonize The Pressor Effect
The increasing blood pressure effect of BIORPHEN is decreased in patients receiving:
- α-adrenergic antagonists
- Phosphodiesterase Type 5 inhibitors
- Mixed α- and β-receptor antagonists
- Calcium channel blockers, such as nifedipine
- Benzodiazepines
- ACE inhibitors
- Centrally acting sympatholytic agents, such as reserpine, guanfacine
Read the entire FDA prescribing information for Biorphen (Phenylephrine Hydrochloride Injection )
&Copy; Biorphen Patient Information is supplied by Cerner Multum, Inc. and Biorphen Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.