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Aplisol

Aplisol (Tuberculin Purified Protein Derivative) side effects drug center

 

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SIDE EFFECTS

 

Aplisol Side Effects Center

What Is Aplisol?

Aplisol (tuberculin purified protein derivative, diluted [stabilized solution]) is a purified protein fraction used as an aid in the detection of infection with Mycobacterium tuberculosis.

What Are Side Effects of Aplisol?

Side effects of Aplisol include:

  • reactions at the test site (pain, itching, discomfort. blisters, ulceration, or tissue death),
  • scarring at the test site (in strong positive test reactions)
  • local hypersensitivity reactions (redness, itching, swelling, hives, and rash), and
  • systemic allergic reactions (including rash, hives, skin swelling, itching, and anaphylaxis)

Dosage for Aplisol

The 0.1 mL dose of Aplisol is equivalent to the 5 tuberculin units (TU) dose of Tuberculin PPD, which is the standard strength used for intradermal Mantoux testing.

Aplisol In Children

Because their immune systems are immature, many neonates and infants under 6 weeks of age, who are infected with

  • M. tuberculosis
    • , may not have a delayed hypersensitivity reaction to a tuberculin test. Older infants and children develop tuberculin sensitivity 3- 6 weeks, and up to 3 months, after initial infection Infants and children who have been exposed to persons with active tuberculosis should be considered positive when reaction to the tuberculin skin test measures >5 mm. Those children younger than 4 years of age who are exposed to persons at increased risk to acquire tuberculosis are considered positive when reaction measures >10 mm. Children with minimal risk exposure to tuberculosis would be considered positive when reaction measures >15 mm.

    What Drugs, Substances, or Supplements Interact with Aplisol?

    Aplisol may interact with other medicines such as:

    Tell your doctor all medications and supplements you use.

    Aplisol During Pregnancy and Breastfeeding

    Tell your doctor if you are pregnant or plan to become pregnant before using Aplisol. Tuberculin skin testing is considered valid and safe throughout pregnancy. The risk of unrecognized tuberculosis and the postpartum contact between a mother with active disease and an infant leaves the infant in grave danger of tuberculosis and complications such as tuberculous meningitis. Consult your doctor before breastfeeding.

    Additional Information

    Our Aplisol (tuberculin purified protein derivative, diluted [stabilized solution]) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

    This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

     

    Aplisol Professional Information

    SIDE EFFECTS

    In highly sensitive individuals, strongly positive reactions including vesiculation, ulceration or necrosis may occur at the test site. Cold packs or topical steroid preparations may be employed for symptomatic relief of the associated pain, pruritus and discomfort.

    Strongly positive test reactions may result in scarring at the test site.

    Local hypersensitivity reactions may occur at the injection site including erythema, pruritus, edema, urticaria and rash.

    Systemic allergic reactions including anaphylaxis/anaphylactoid reactions have been reported to occur in association with the use of Aplisol. The reactions, including anaphylaxis, generally occurred within 24 hours of exposure and manifestations included rash, urticaria, edema/angioedema and pruritus.

    To report SUSPECTED ADVERSE REACTIONS, contact JHP at 1-866-923-2547 or MEDWATCH at 888-INFO-FDA (1-888-463-6332) or http://www.fda.gov/medwatch/.

    Read the entire FDA prescribing information for Aplisol (Tuberculin Purified Protein Derivative)

    © Aplisol Patient Information is supplied by Cerner Multum, Inc. and Aplisol Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.