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Adrucil

Adrucil (Fluorouracil Injection) side effects drug center

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    • Adrucil Side Effects Center

    What Is Adrucil?

    Adrucil (fluorouracil injection) is a nucleoside metabolic inhibitor indicated for the treatment of patients with adenocarcinoma of the colon and rectum, adenocarcinoma of the breast, gastric adenocarcinoma, or pancreatic adenocarcinoma. The brand name Adrucil has been discontinued. It may be available in generic form.

    What Are Side Effects of Adrucil?

    Common side effects of Adrucil (fluorouracil) include:

    • low red and white blood cells and platelets,
    • gastrointestinal ulcers,
    • nausea,
    • vomiting,
    • severe allergic reaction (anaphylaxis),
    • other allergic reactions,
    • involuntary eye movement,
    • headache,
    • dry or cracking skin,
    • skin sensitivity to sunlight (redness or dark spots on skin),
    • tear duct obstruction,
    • changes in vision,
    • tearing,
    • eye sensitivity to light,
    • euphoria,
    • inflammation of veins caused by blood clots,
    • nosebleed, and
    • nail changes (including loss of nails).

    Dosage for Adrucil

    The recommended dose and regimen for Adrucil (fluorouracil) depends on the condition being treated.

    What Drugs, Substances, or Supplements Interact with Adrucil?

    Adrucil (fluorouracil) may interact with anticoagulants. Tell your doctor all medications and supplements you use.

    Adrucil During Pregnancy or Breastfeeding

    Adrucil (fluorouracil) is not recommended for use during pregnancy; it may harm a fetus. Females of reproductive potential are advised to use effective contraception during treatment with Adrucil (fluorouracil) and for up to 3 months after stopping. Adrucil (fluorouracil) may damage spermatozoa. Males with female partners of reproductive potential are advised to use effective contraception during and for 3 months after stopping. Because of the potential for serious adverse reactions in nursing infants, breastfeeding is not recommended while using Adrucil (fluorouracil).

    Additional Information

    Our Adrucil (fluorouracil injection) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

    Adrucil Consumer Information

    Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

    Stop using fluorouracil topical and call your doctor at once if you have:

    • severe pain or swelling of treated skin;
    • severe itching, burning, or irritation;
    • new or worsening skin sores;
    • fever, chills; or
    • severe stomach pain, bloody diarrhea, vomiting.

    Before your skin begins to heal it will become red, dry, tender, and crusty. This is a normal skin reaction, even if these symptoms get worse for a short time. Gradually, the dead skin will begin to shed off and you'll see raw skin appear. Ask your doctor when to stop using the medicine after you notice signs of healing.

    Common side effects may include:

    • skin pain, itching, burning, or irritation;
    • skin darkening or scarring;
    • skin redness and swelling; or
    • small blood vessels under the skin.

    This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Read the entire detailed patient monograph for Adrucil (Fluorouracil Injection)

    Adrucil Professional Information

    SIDE EFFECTS

    The following adverse reactions are discussed in more detail in other sections of the labeling:

    • Increased risk of serious or fatal adverse reactions in patients with low or absent dipyrimidine dehydrogenase activity [see WARNINGS AND PRECAUTIONS]
    • Cardiotoxicity [see WARNINGS AND PRECAUTIONS]
    • Hyperammonemic encephalopathy [see WARNINGS AND PRECAUTIONS]
    • Neurologic toxicity [see WARNINGS AND PRECAUTIONS]
    • Diarrhea [see WARNINGS AND PRECAUTIONS]
    • Palmar-plantar erythrodysesthesia (hand-foot syndrome) [see WARNINGS AND PRECAUTIONS]
    • Myelosuppression [see WARNINGS AND PRECAUTIONS]
    • Mucositis [see WARNINGS AND PRECAUTIONS]
    • Increased risk of elevated INR when administrated with warfarin [see WARNINGS AND PRECAUTIONS]

    Postmarketing Experience

    The following adverse reactions have been identified during postapproval use of fluorouracil. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

    Hematologic: pancytopenia [see WARNINGS AND PRECAUTIONS]

    Gastrointestinal: gastrointestinal ulceration, nausea, vomiting

    Allergic Reactions: anaphylaxis and generalized allergic reactions

    Neurologic: nystagmus, headache

    Dermatologic: dry skin; fissuring; photosensitivity, as manifested by erythema or increased pigmentation of the skin; vein pigmentation

    Ophthalmic: lacrimal duct stenosis, visual changes, lacrimation, photophobia

    Psychiatric: euphoria

    Miscellaneous: thrombophlebitis, epistaxis, nail changes (including loss of nails)

    Read the entire FDA prescribing information for Adrucil (Fluorouracil Injection)

    © Adrucil Patient Information is supplied by Cerner Multum, Inc. and Adrucil Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.