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Colum: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Colum - General Information

Colum is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Colum diminishes gastric acid and pepsin secretion. Colum also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ganglionic parasympathetic inhibitor. It has not been shown to be effective in contributing to the healing of peptic ulcer, decreasing the rate of recurrence, or preventing complications.

 

Pharmacology of Colum

Colum diminishes gastric acid and pepsin secretion. Colum also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ganglionic parasympathetic inhibitor.

 

Additional information about Colum

Colum Indication

For use as adjunctive therapy in the treatment of peptic ulcer. It has not been

Mechanism Of Action
Colum is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon.
Generic Name
Mepenzolate
Synonyms
1-Methyl-3-piperidyl benzilate methyl bromide; Mepenzolate bromide; Mepenzolic acid; N-Methyl-3-piperidyl benzilate methyl bromide; N-Methyl-3-piperidyldiphenylglycolate methobromide
Drug Category
Anticholinergic Agents; Parasympatholytics
Drug Type
Small Molecule; Approved
Other Brand Names containing Mepenzolate
Cantil; Cantilaque; Cantilon; Cantril; Colibantil; Colopiril; Colum; Delevil; Eftoron; Gastropidil; Mepenzolon; Tralanta; Trancolon;
Absorption
Between 3 and 22% of an orally administered dose is excreted in the urine over a 5-day period, with the majority of the radioactivity appearing on Day 1. The remainder appears in the next 5 days in the feces and presumably has not been absorbed.
Toxicity (Overdose)
The signs and symptoms of overdosage are headache; nausea; vomiting; blurred vision; dilated pupils; hot, dry skin; dizziness; dryness of the mouth; difficulty in swallowing; and CNS stimulation. A curare-like action may occur (i.e., neuromuscular blockade leading to muscular weakness and possible
Dosage Forms of Colum
Tablet Oral
Chemical IUPAC Name
(1,1-dimethylpiperidin-1-ium-3-yl) 2-hydroxy-2,2-di(phenyl)acetate
Chemical Formula
C21H26NO3
Organisms Affected
Humans and other mammals