Stimate
Stimate - General Information
Stimate is a chemical that is similar to a hormone found naturally in your body. It increases urine concentration and decreases urine production. Stimate is used to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions, allowing you to sleep through the night without awakening to urinate. It is also used to treat specific types of diabetes insipidus and conditions after head injury or pituitary surgery.
Pharmacology of Stimate
Stimate is a synthetic analogue of the natural pituitary hormone 8-arginine vasopressin (ADH), an antidiuretic hormone affecting renal water conservation. Stimate is indicated as antidiuretic replacement therapy in the management of central diabetes insipidus and for the management of the temporary polyuria and polydipsia following head trauma or surgery in the pituitary region and is also indicated for the management of primary nocturnal enuresis.
Stimate for patients
Stimate Interactions
Although the pressor activity of Desmopressin is very low compared to its antidiuretic activity, large doses of Desmopressin Tablets should be used with other pressor agents only with careful patient monitoring.
Stimate Contraindications
Desmopressin tablets are contraindicated in individuals with known hypersensitivity to desmopressin acetate or to any of the components of Desmopressin tablets.
Additional information about Stimate
Stimate Indication: For the management of primary nocturnal enuresis and indicated as antidiuretic replacement therapy in the management of central diabetes insipidus and for the management of the temporary polyuria and polydipsia following head trauma or surgery in the pituitary
Mechanism Of Action: Stimate emulates the actions of the natural pituitary hormone 8-arginine vasopressin (ADH).
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Desmopressin
Synonyms: 1-Deamino-8-D-arginine vasopressin; 1-Desamino-8-D-arginine vasopressin; 1-Desamino-8-d-arginine-vasopressin; Desmopresina [INN-Spanish]; Desmopressine [INN-French]; Desmopressinum [INN-Latin]; Desmopressin acetate; DDAVP
Drug Category: Renal Agents
Drug Type: Biotech; Approved
Other Brand Names containing Desmopressin: Concentraid; Stimate; Adiuretin;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: 50%
Biotransformation: Not Available
Half Life: 1.5-2.5 hours
Dosage Forms of Stimate: Spray, metered Nasal
Aerosol, metered Nasal
Tablet Oral
Spray Nasal
Solution Nasal
Tablet, orally disintegrating Sublingual
Liquid Intravenous
Chemical IUPAC Name: N-[1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-(phenylmethyl)1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
Chemical Formula: C46H64N14O12S2
Desmopressin on Wikipedia: https://en.wikipedia.org/wiki/Desmopressin
Organisms Affected: Humans and other mammals
