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Stimate: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Stimate - General Information

Stimate is a chemical that is similar to a hormone found naturally in your body. It increases urine concentration and decreases urine production. Stimate is used to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions, allowing you to sleep through the night without awakening to urinate. It is also used to treat specific types of diabetes insipidus and conditions after head injury or pituitary surgery.

 

Pharmacology of Stimate

Stimate is a synthetic analogue of the natural pituitary hormone 8-arginine vasopressin (ADH), an antidiuretic hormone affecting renal water conservation. Stimate is indicated as antidiuretic replacement therapy in the management of central diabetes insipidus and for the management of the temporary polyuria and polydipsia following head trauma or surgery in the pituitary region and is also indicated for the management of primary nocturnal enuresis.

 

Stimate for patients

 

Stimate Interactions

Although the pressor activity of Desmopressin is very low compared to its antidiuretic activity, large doses of Desmopressin Tablets should be used with other pressor agents only with careful patient monitoring.

 

Stimate Contraindications

Desmopressin tablets are contraindicated in individuals with known hypersensitivity to desmopressin acetate or to any of the components of Desmopressin tablets.

 

Additional information about Stimate

Stimate Indication

For the management of primary nocturnal enuresis and indicated as antidiuretic replacement therapy in the management of central diabetes insipidus and for the management of the temporary polyuria and polydipsia following head trauma or surgery in the pituitary

Mechanism Of Action
Stimate emulates the actions of the natural pituitary hormone 8-arginine vasopressin (ADH).
Generic Name
Desmopressin
Synonyms
1-Deamino-8-D-arginine vasopressin; 1-Desamino-8-D-arginine vasopressin; 1-Desamino-8-d-arginine-vasopressin; Desmopresina [INN-Spanish]; Desmopressine [INN-French]; Desmopressinum [INN-Latin]; Desmopressin acetate; DDAVP
Drug Category
Renal Agents
Drug Type
Biotech; Approved
Other Brand Names containing Desmopressin
Concentraid; Stimate; Adiuretin;
Protein Binding
50%
Half Life
1.5-2.5 hours
Dosage Forms of Stimate
Spray, metered Nasal
Chemical IUPAC Name
N-[1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-(phenylmethyl)1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
Chemical Formula
C46H64N14O12S2
Organisms Affected
Humans and other mammals