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Securit: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Securit - General Information

A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent. [PubChem]

 

Pharmacology of Securit

Securit, a benzodiazepine not transformed to active metabolites, is used to treat anxiety, status epilepticus, and for sedation induction and anterograde amnesia.

 

Securit for patients

Lorazepam is a benzodiazepine used for the treatment of anxiety, anxiety with depression, and insomnia. Inform your physician if you are pregnant or nursing. Lorazepam may cause dizziness and drowsiness; use caution while driving or operating hazardous machinery. Do not take any other sedating drugs or drink alcohol while taking this medication. Lorazepam may be habit forming. It is advisable that patients consult with their physician before changing the dose. Withdrawal symptoms may occur after you stop taking it. This medication may be taken with or without food.

 

Securit Interactions

Tablets: The benzodiazepines, including lorazepam, produce CNS-depressant effects when administered with such medications as barbiturates or alcohol.

Injection: Lorazepam injection, like other injectable benzodiazepines, produces depression of the central nervous system when administered with ethyl alcohol, phenothiazines, barbiturates, MAO inhibitors, and other antidepressants.When scopolamine is used concomitantly with injectable lorazepam, an increased incidence of sedation, hallucinations, and irrational behavior has been observed.

 

Securit Contraindications

Tablets: Lorazepam is contraindicated in patients with known sensitivity to the benzodiazepines or with acute narrow-angle glaucoma.

Injection: Lorazepam injection is indicated in adult patients for preanesthetic medication, producing sedation (sleepiness or drowsiness), relief of anxiety, and a decreased ability to recall events related to the day of surgery. It is most useful in those patients who are anxious about their surgical procedure and who would prefer to have diminished recall of the day of surgery.

 

Additional information about Securit

Securit Indication: For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms Mechanism Of Action: Securit binds to central benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways. Drug Interactions: Clozapine Increased risk of toxicityEthotoin Possible increased levels of the hydantoin, decrease of benzodiazepineFosphenytoin Possible increased levels of the hydantoin, decrease of benzodiazepineMephenytoin Possible increased levels of the hydantoin, decrease of benzodiazepinePhenytoin Possible increased levels of the hydantoin, decrease of benzodiazepineKava Kava increases the effect of the benzodiazepine Food Interactions: Avoid alcohol.Take with food.Avoid excessive quantities of coffee or tea (Caffeine). Generic Name: Lorazepam Synonyms: (+/-)-Lorazepam; L-Lorazepam Acetate; O-Chlorooxazepam; O-Chloroxazepam Drug Category: Anti-anxiety Agents; Hypnotics and Sedatives; Antiemetics; Anticonvulsants; Benzodiazepines Drug Type: Small Molecule; Approved Other Brand Names containing Lorazepam: Almazine; Alzapam; Anxiedin; Aplacassee; Ativan; Bonatranquan; Delormetazepam; Emotival; Idalprem; Lorabenz; Lorax; Loraz; Lorazepam Intensol; Lorsilan; Pro Dorm; Psicopax; Punktyl; Quait; Securit; Sedatival; Sedazin; Somagerol; Tavor; Temesta; Wypax; Absorption: Readily absorbed with an absolute bioavailability of 90%. Toxicity (Overdose): Somnolence, confusion, and coma, LD50=3178mg/kg (orally in mice). Protein Binding: 85% Biotransformation: Hepatic Half Life: 12 hours Dosage Forms of Securit: Liquid IntravenousTablet OralTablet Sublingual Chemical IUPAC Name: 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one Chemical Formula: C15H10Cl2N2O2 Lorazepam on Wikipedia: https://en.wikipedia.org/wiki/Lorazepam Organisms Affected: Humans and other mammals