Ridaura: Full Drug Profile

Ridaura - General Information

Ridaura is a organogold compound classified by the World Health Organization as an antirheumatic agent. Ridaura appears to induce heme oxygenase 1 (HO-1) mRNA. Heme oxygenase 1 is an inducible heme-degrading enzyme with anti-inflammatory properties.

Pharmacology of Ridaura

Ridaura is a gold salt used in treating inflammatory arthritis. Gold salts are called second-line drugs because they are often considered when the arthritis progresses in spite of antiinflammatory drugs (NSAIDs and corticosteroids).

Ridaura for patients

Unlike anti-inflammatory medications, Auranofin does not take effect immediately. In fact, you may have to wait for 3 to 6 months to get any benefit from Auranofin. Auranofin prevents or suppresses joint swelling, but does not cure rheumatoid arthritis.

Ridaura Interactions

Auranofin should be avoided by patients with a history of serious reaction to any gold medication, including Solganal and Myochrysine. Auranofin should not be used together with penicillamine (Depen, Cuprimine), another arthritis medication. It should also be avoided in patients with blood, liver or kidney diseases, recent radiation treatment, or uncontrolled diabetes. Patients should report to their practitioners any new rashes, itching, mouth sores, or unusual taste while taking auranofin. Gold is excreted slowly from the body. Safety and effectiveness in children has not been established.

Ridaura Contraindications

Additional information about Ridaura

Ridaura Indication

Used in the treatment of active, progressive or destructive forms of inflammatory arthritis, such as adult rheumatoid arthritis.

Mechanism Of Action

Exactly how auranofin works is not well understood. In patients with inflammatory arthritis, such as adult and juvenile rheumatoid arthritis, gold salts can decrease the inflammation of the joint lining. This effect can prevent destruction of bone and cartilage.

Food Interactions

Take with food to reduce irritation.

Generic Name

Auranofin

Synonyms

Auroafen

Drug Category

Antirheumatic Agents, Gold

Drug Type

Small Molecule; Approved

Other Brand Names containing Auranofin

Ridaura;

Toxicity (Overdose)

Oral, rat: LD₅₀ = > 2000 mg/kg. Symptoms of overdose may include diarrhoea, vomiting, abdominal cramps, and symptoms of hypersensitivity (such as skin rash, hives, itching, and difficulty breathing).

Dosage Forms of Ridaura

Capsule Oral

Chemical IUPAC Name

gold(+1) cation; 3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate; triethylphosphanium

Chemical Formula

C20H35AuO9PS+

Auranofin on Wikipedia

https://en.wikipedia.org/wiki/Auranofin

Organisms Affected

Humans and other mammals