Prociclide
Prociclide - General Information
Prociclide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Dasovas (FM), Noravid, and Prociclide in a variety of countries, but is currently not approved in the USA. The manufacturer is Gentium.
Pharmacology of Prociclide
Prociclide is a deoxyribonucleic acid derivative extracted from mammalian organs, which has been developed for the treatment of a number of vascular disorders. It appears to increase fibrinolysis and may possess antithrombotic, antiatherosclerotic and anti-ischaemic actions, probably due to its ability to selectively increase prostaglandin I2 and E2 levels and to increase tissue plasminogen activator and decrease plasminogen activator inhibitor function. Prociclide is available as an intravenous and intramuscular preparation, and also as an oral formulation for long term use.
Additional information about Prociclide
Prociclide Indication: Prociclide is used to treat or prevent a failure of normal blood flow (occlusive venous disease, OVD) in the liver of patients who have had bone marrow transplants or received certain drugs such as oral estrogens, mercaptopurine, and many others.
Mechanism Of Action: The drug appears to prevent the formation of blood clots and to help dissolve blood clots by increasing levels of prostaglandin I2, E2, and prostacyclin, altering platelet activity, increasing tissue plasminogen activator function, and decreasing activity of tissue plasminogen activator inhibitor. Prostaglandin I2 relaxes the smooth muscle of blood vessels and prevents platelets from adhering to each other. Prostaglandin E2 at certain concentrations also inhibits platelet aggregation. Moreover, the drug provides additional beneficial anti-inflammatory and antiischemic activities as recent sudies have shown. It is yet unclear, if the latter effects can be utilized clinically (e.g., treatment of ischemic stroke).
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Defibrotide
Synonyms: Not Available
Drug Category: Antithrombotic Agents
Drug Type: Biotech; Approved; Investigational
Other Brand Names containing Defibrotide: Dasovas; Noravid; Prociclide;
Absorption: Bioavailability is 58-70% following oral administration, compared to parenteral forms (i.v. and i.m. = 100%).
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: t1/2-alpha = minutes (10-20 minutes in rat); t1/2-beta = a few hours
Dosage Forms of Prociclide: Solution Oral
Solution Intravenous
Solution Intramuscular
Chemical IUPAC Name: Not Available
Chemical Formula: Not Available
Defibrotide on Wikipedia: https://en.wikipedia.org/wiki/Defibrotide
Organisms Affected: Humans and other mammals
