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Prent: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Prent - General Information

A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. [PubChem]

 

Pharmacology of Prent

Prent is a cardioselective, beta-adrenoreceptor blocking agent, which possesses mild intrinsic sympathomimetic activity (ISA) in its therapeutically effective dose range. In general, beta-blockers reduce the work the heart has to do and allow it to beat more regularly. Prent has less antagonistic effects on peripheral vascular ß2-receptors at rest and after epinephrine stimulation than nonselective beta-antagonists. Low doses of acebutolol produce less evidence of bronchoconstriction than nonselective agents like propranolol but more than atenolol.

 

Prent for patients

 

Prent Interactions

Catecholamine-depleting drugs, such as reserpine, may have an additive effect when given with beta-blocking agents. Patients treated with acebutolol plus catecholamine depletors should, therefore, be observed closely for evidence of marked bradycardia or hypotension which may present as vertigo, syncope/presyncope, or orthostatic changes in blood pressure without compensatory tachycardia. Exaggerated hypertensive responses have been reported from the combined use of beta-adrenergic antagonists and alpha-adrenergic stimulants, including those contained in proprietary cold remedies and vasoconstrictive nasal drops. Patients receiving beta-blockers should be warned of this potential hazard.

Blunting of the antihypertensive effect of beta-adrenoceptor blocking agents by nonsteroidal anti-inflammatory drugs has been reported.

No significant interactions with digoxin, hydrochlorothiazide, hydralazine, sulfinpyrazone, oral contraceptives, tolbutamide, or warfarin have been observed.

 

Prent Contraindications

Acebutolol hydrochloride capsules are contraindicated in: 1) persistently severe bradycardia; 2) second- and third-degree heart block; 3) overt cardiac failure; and 4) cardiogenic shock.

 

Additional information about Prent

Prent Indication: For the management of hypertension and ventricular premature beats in adults. Mechanism Of Action: Prent is a selective β1-receptor antagonist. Activation of β1-receptors by epinephrine increases the heart rate and the blood pressure, and the heart consumes more oxygen. Prent blocks these receptors which reverses the effects of epinephrine, lowering the heart rate and blood pressure. In addition, beta blockers prevent the release of renin, which is a hormone produced by the kidneys which leads to constriction of blood vessels. Drug Interactions: Acetohexamide Decreased in symptoms of hypoglycemia and increase in time required for the body to compensate for hypoglycemiaChlorpropamide Decreased in symptoms of hypoglycemia and increase in time required for the body to compensate for hypoglycemiaDisopyramide Decreased in symptoms of hypoglycemia and increase in time required for the body to compensate for hypoglycemiaGliclazide Decreased in symptoms of hypoglycemia and increase in time required for the body to compensate for hypoglycemiaGlipizide Decreased in symptoms of hypoglycemia and increase in time required for the body to compensate for hypoglycemiaGlibenclamide Decreased in symptoms of hypoglycemia and increase in time required for the body to compensate for hypoglycemiaLidocaine Decreased in symptoms of hypoglycemia and increase in time required for the body to compensate for hypoglycemiaRepaglinide Decreased in symptoms of hypoglycemia and increase in time required for the body to compensate for hypoglycemiaTolazamide Decreased in symptoms of hypoglycemia and increase in time required for the body to compensate for hypoglycemiaTolbutamide Decreased in symptoms of hypoglycemia and increase in time required for the body to compensate for hypoglycemiaClonidine Increased hypertension when clonidine stoppedDihydroergotamine Ischemia with risk of gangreneErgotamine Ischemia with risk of gangreneMethysergide Ischemia with risk of gangreneEpinephrine Hypertension, then bradycardiaIbuprofen Risk of inhibition of renal prostaglandinsIndomethacin Risk of inhibition of renal prostaglandinsPiroxicam Risk of inhibition of renal prostaglandinsPrazosin Risk of hypotension at the beginning of therapyVerapamil Increased effect of both drugsIsoproterenol AntagonismSalmeterol AntagonismTerbutaline AntagonismDihydroergotoxine Ischemia with risk of gangreneErgonovine Ischemia with risk of gangreneFenoterol AntagonismGlisoxepide The beta-blocker decreases the symptoms of hypoglycemiaOrciprenaline AntagonismPirbuterol AntagonismFenoterol AntagonismInsulin-aspart The beta-blocker decreases the symptoms of hypoglycemiaInsulin-detemir The beta-blocker decreases the symptoms of hypoglycemiaInsulin-glargine The beta-blocker decreases the symptoms of hypoglycemiaInsulin-glulisine The beta-blocker decreases the symptoms of hypoglycemiaInsulin-lispro The beta-blocker decreases the symptoms of hypoglycemiaLidocaine The beta-blocker increases the effect and toxicity of lidocainePirbuterol AntagonismOrciprenaline Antagonsim Food Interactions: Take without regard to meals; absorption rate and maximal concentration are slightly reduced but the extent of absorption is not affected. Generic Name: Acebutolol Synonyms: dl-Acebutolol; Acetobutolol; Acebutololo; Acebutolol HCL Drug Category: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Antihypertensive Agents Drug Type: Small Molecule; Approved Other Brand Names containing Acebutolol: Monitan; Neptal; Prent; Sectral; Absorption: Well absorbed from the Gl tract with an absolute bioavailability of approximately 40% for the parent compound. In Toxicity (Overdose): Symptoms of overdose include extreme bradycardia, advanced atrioventricular block, intraventricular conduction defects, hypotension, severe congestive heart failure, seizures, and in susceptible patients, bronchospasm, and hypoglycemia. Protein Binding: 26% Biotransformation: Subject to extensive first-pass hepatic biotransformation (primarily to diacetolol). Half Life: The plasma elimination half-life is approximately 3 to 4 hours. The half-life of its metabolite, diacetolol, is 8 to 13 hours. Dosage Forms of Prent: Tablet Oral Chemical IUPAC Name: N-[3-acetyl-4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]butanamide Chemical Formula: C18H28N2O4 Acebutolol on Wikipedia: https://en.wikipedia.org/wiki/Acebutolol Organisms Affected: Humans and other mammals