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Pneumopent: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Pneumopent - General Information

Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. [PubChem]

 

Pharmacology of Pneumopent

Pneumopent is an antiprotozoal agent. It is an aromatic diamidine, and is known to have activity against Pneumocystis carinii. The exact nature of its antiprotozoal action is unknown. in vitro studies with mammalian tissues and the protozoan Crithidia oncopelti indicate that the drug interferes with nuclear metabolism producing inhibition of the synthesis of DNA, RNA, phospholipids and proteins. Little is known about the drug's pharmacokinetics. The medication is also useful in Leishmaniasis and in prophylaxis against sleeping sickness caused by Trypanosoma brucei gambiense. Hydration before treatment lessens the incidence and severity of side effects, which include liver or kidney dysfunction, hypertension, hypotension, hypoglycemia, hypocalemia, leukopenia, thrombcytopenia, anemia, and allergic reaction. It is generally well-tolerated.

 

Pneumopent for patients

 

Pneumopent Interactions

 

Pneumopent Contraindications

Once the diagnosis of Pneumocystis carinii pneumonia has been firmly established, there are no absolute contraindications to the use of pentamidine isethionate.

 

Additional information about Pneumopent

Pneumopent Indication

For the treatment of pneumonia due to Pneumocystis carinii.

Mechanism Of Action
The mode of action of pentamidine is not fully understood. It is thought that the drug interferes with nuclear metabolism producing inhibition of the synthesis of DNA, RNA, phospholipids, and proteins.
Drug Interactions
Mesoridazine Increased risk of cardiotoxicity and arrhythmias
Generic Name
Pentamidine
Synonyms
Pentamidine Isethionate; Pentamide; 4, 4'-Diamidinodiphenoxypentane; PNT; 1,3-bis(4-amidinophenoxy)pentane
Drug Category
Trypanocidal Agents; Antiprotozoal Agents; Antifungal Agents
Drug Type
Small Molecule; Approved
Other Brand Names containing Pentamidine
NebuPent; Pentacarinat; Pentam; Pentam 300; Pneumopent;
Absorption
Absorbed poorly through the gastrointestinal tract and is usually administered parenterally.
Toxicity (Overdose)
Symptoms of overdose include pain, nausea, anorexia, hypotension, fever, rash, bad taste in mouth, confusion/hallucinations, dizziness, and diarrhea.
Protein Binding
69%
Biotransformation
Hepatic.
Half Life
9.1-13.2 hours
Dosage Forms of Pneumopent
Powder, for solution Intravenous
Chemical IUPAC Name
4-[5-(4-carbamimidoylphenoxy)pentoxy]benzenecarboximidamide
Chemical Formula
C19H24N4O2
Organisms Affected
Pneumocystis carinii