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Norflex: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Norflex - General Information

A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. [PubChem]

 

Pharmacology of Norflex

Norflex is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions. Norflex is an anticholinergic with a predominantly central effect and only a weak peripheral effect. In addition, it has mild antihistaminic and local anaesthetic properties. Parkinson's syndrome is the consequence of a disturbed balance between cholinergic and dopaminergic neurotransmission in the basal ganglia caused by a decrease in dopamine. Norflex restores the physiological equilibrium and has a favourable effect on the rigidity and tremor of Parkinson's disease and Parkinsonian syndromes. The effect is somewhat less on bradykinesia.

 

Norflex for patients

 

Norflex Interactions

No information provided.

 

Norflex Contraindications

Contraindicated in patients with glaucoma, pyloric or duodenal obstruction, stenosing peptic ulcers, prostatic hypertrophy or obstruction of the bladder neck, cardiospasm (megaesophagus) and myasthenia gravis.

Contraindicated in patients who have demonstrated a previous hypersensitivity to the drug.

 

Additional information about Norflex

Norflex Indication: Indicated for the treatment of Parkinson's disease. Mechanism Of Action: Norflex binds to both histamine H1 receptors and NMDA receptors. It restores the motor disturbances induced by neuroleptics, in particular the hyperkinesia. The dopamine deficiency in the striatum increases the stimulating effects of the cholinergic system. This stimulation is counteracted by the anticholinergic effect of orphenadrine. It may have a relaxing effect on skeletal muscle spasms and it has a mood elevating effect. Drug Interactions: Docetaxel The agent increases the serum levels and toxicity of docetaxelDonepezil Possible antagonism of actionGalantamine Possible antagonism of actionRivastigmine Possible antagonism of action Food Interactions: Not Available Generic Name: Orphenadrine Synonyms: O-Methyldiphenhydramine; Orphenadrine Citrate; Orphenadine; Orphenadrin; Orphenate; Orphenedrine; Mephenamine Drug Category: Antiparkinson Agents; Antidyskinetics; Skeletal Muscle Relaxants Drug Type: Small Molecule; Approved Other Brand Names containing Orphenadrine: Antiflex; Banflex; Biorphen; Brocadisipal; Brocasipal; Disipal; Flexoject; Mio-Rel; Myolin; Myotrol; Norflex; Orfro; Absorption: Orphenadrine is almost completely absorbed in the gastrointestinal tract. Toxicity (Overdose): Oral, mouse LD50 = 100 mg/kg; oral, rat LD50 = 255 mg/kg Protein Binding: 95% Biotransformation: Biotransformation occurs mainly in the liver. Pharmacologically active metabolites are N-demethyl orphenadrine and N,N-didemethyl orphenadrine. Half Life: 13-20 hours Dosage Forms of Norflex: Tablet, extended release OralTablet OralLiquid Intravenous Chemical IUPAC Name: N,N-dimethyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine Chemical Formula: C18H23NO Orphenadrine on Wikipedia: https://en.wikipedia.org/wiki/Orphenadrine Organisms Affected: Humans and other mammals