Nimergoline Base: Full Drug Profile

Nimergoline Base - General Information

An ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It has been suggested to ameliorate cognitive deficits in cerebrovascular disease. [PubChem]

Pharmacology of Nimergoline Base

Nimergoline Base is a potent vasodilator (improves brain blood flow). On the cerebral level it prompts a lowering of vascular resistance, an increase in arterial flow and stimulates the use of oxygen and glucose. Nimergoline Base also improves blood circulation in the lungs and limbs and has been shown to inhibit blood platelet aggregation.

Additional information about Nimergoline Base

Nimergoline Base Indication

For the treatment of senile dementia, migraines of vascular origin, transient ischemia, platelet hyper-aggregability, and macular degeneration.

Mechanism Of Action

Nimergoline Base acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation. Therefore the mechanism of Nimergoline Base is to increase vascular circulation in the brain, thereby enhancing the transmission of nerve signals across the nerve fibres, which secrete acetylcholine as a neural transmitter.

Generic Name

Nicergoline

Drug Category

Nootropic Agents; Vasodilator Agents

Drug Type

Small Molecule; Approved

Other Brand Names containing Nicergoline

MNE; Nargoline; Nicergolin [German]; Nicergolina [Dcit]; Nicergoline [Usan-Ban-Inn-Jan]; Nicergolinum [Inn-Latin]; Nicotergoline; Nimergoline; Nimergoline Base; Sermion; Vasospan;

Chemical Formula

C24H26BrN3O3

Nicergoline on Wikipedia

https://en.wikipedia.org/wiki/Nicergoline

Organisms Affected

Humans and other mammals