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Neurobloc (Solstice Neurosciences): Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Neurobloc (Solstice Neurosciences) - General Information

Neurotoxin produced by fermentation of clostridium botulinum type B. The protein exists in noncovalent association with hemagglutinin and nonhemagglutinin proteins as a neurotoxin complex. The neurotoxin complex is recovered from the fermentation process and purified through a series of precipitation and chromatography steps.

 

Pharmacology of Neurobloc (Solstice Neurosciences)

Neurobloc (Solstice Neurosciences) inhibits acetylcholine release at the neuromuscular junction via a three stage process: 1) Heavy Chain mediated neurospecific binding of the toxin, 2) internalization of the toxin by receptor-mediated endocytosis, and 3) ATP and pH dependent translocation of the Light Chain to the neuronal cytosol where it acts as a zinc-dependent endoprotease cleaving polypeptides essential for neurotransmitter release.

 

Neurobloc (Solstice Neurosciences) for patients

 

Neurobloc (Solstice Neurosciences) Interactions

Co-administration of MYOBLOC and aminoglycosides or other agents interfering with neuromuscular transmission (e.g., curare-like compounds) should only be performed with caution as the effect of the toxin may be potentiated.

The effect of administering different botulinum neurotoxin serotypes at the same time or within less than 4 months of each other is unknown. However, neuromuscular paralysis may be potentiated by co-administration or overlapping administration of different botulinum toxin serotypes.

 

Neurobloc (Solstice Neurosciences) Contraindications

MYOBLOC is contraindicated in patients with a known hypersensitivity to any ingredient in the formulation.

 

Additional information about Neurobloc (Solstice Neurosciences)

Neurobloc (Solstice Neurosciences) Indication

For the treatment of patients with cervical dystonia to reduce the severity of abnormal head position and neck pain associated with cervical dystonia.

Mechanism Of Action
Neurobloc (Solstice Neurosciences) binds to and cleaves the synaptic Vesicle Associated Membrane Protein (VAMP, also known as synaptobrevin) which is a component of the protein complex responsible for docking and fusion of the synaptic vesicle to the presynaptic membrane, a necessary step to neurotransmitter release.
Generic Name
Botulinum Toxin Type B
Synonyms
BTX-B; Botulinum neurotoxin type B precursor
Drug Category
Antidystonic Agents
Drug Type
Biotech; Approved
Other Brand Names containing Botulinum Toxin Type B
Myobloc (Solstice Neurosciences); Neurobloc (Solstice Neurosciences);
Absorption
Though pharmacokinetic or ADME studies were not performed, Botulinum Toxin Type B is not expected to be present in the peripheral blood at measurable levels following IM injection at the recommended doses.
Toxicity (Overdose)
One unit of Botulinum Toxin Type B corresponds to the calculated median lethal intraperitoneal dose (LD50) in mice.
Dosage Forms of Neurobloc (Solstice Neurosciences)
Injection, solution Intramuscular
Chemical Formula
C6760H10447N1743O2010S32
Botulinum Toxin Type B on Wikipedia
https://en.wikipedia.org/wiki/Botulinum_toxin
Organisms Affected
Humans and other mammals