Mecothane: Full Drug Profile
Mecothane - General Information
A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Mecothane is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, cardiac rate changes, and bronchial spasms. [PubChem]
Pharmacology of Mecothane
Mecothane is a parasympathomimetic (cholinergic) used for the treatment of acute postoperative and postpartum nonobstructive (functional) urinary retention and for neurogenic atony of the urinary bladder with retention. Mecothane, a cholinergic agent, is a synthetic ester which is structurally and pharmacologically related to acetylcholine. It increases the tone of the detrusor urinae muscle, usually producing a contraction sufficiently strong to initiate micturition and empty the bladder. It stimulates gastric motility, increases gastric tone, and often restores impaired rhythmic peristalsis. Mecothane chloride is not destroyed by cholinesterase and its effects are more prolonged than those of acetytcholine.
Mecothane for patients
Bethanechol chloride tablets should preferably be taken one hour before or two hours after meals to avoid nausea or vomiting. Dizziness, lightheadedness or fainting may occur, especially when getting up from a lying or sitting position.
Mecothane Interactions
Special care is required if this drug is given to patients receiving ganglion blocking compounds because a critical fall in blood pressure may occur. Usually, severe abdominal symptoms appear before there is such a fall in the blood pressure.
Mecothane Contraindications
Hypersensitivity to bethanechol chloride tablets, hyperthyroidism, peptic ulcer, latent or active bronchial asthma, pronounced bradycardia or hypotension, vasomotor instability, coronary artery disease, epilepsy, and parkinsonism.
Bethanechol chloride should not be employed when the strength or integrity of the gastrointestinal or bladder wall is in question, or in the presence of mechanical obstruction; when increased muscular activity of the gastrointestinal tract or urinary bladder might prove harmful, as following recent urinary bladder surgery, gastrointestinal resection and anastomosis, or when there is possible gastrointestinal obstruction; in bladder neck obstruction, spastic gastrointestinal disturbances, acute inflammatory lesions of the gastrointestinal tract, or peritonitis; or in marked vagotonia.
Additional information about Mecothane
Mecothane Indication: For the treatment of acute postoperative and postpartum nonobstructive (functional) urinary retention and for neurogenic atony of the urinary bladder with retention. Mechanism Of Action: Mecothane acts by selectively stimulating muscarinic receptors in the parasympathetic nervous system, inducing no affect on nicotinic receptors. Drug Interactions: Not Available Food Interactions: Take on empty stomach: 1 hour before or 2 hours after meals to avoid nausea. Generic Name: Bethanechol Synonyms: Amidopropyldimethylbetaine; Beta-Methyl Carbachol Chloride; Besacholine; Bethaine Choline Chloride; Bethanechol Chloride; BTC; Carbamylmethylcholine Chloride Drug Category: Parasympathomimetics Drug Type: Small Molecule; Approved Other Brand Names containing Bethanechol: Duvoid; Mechotane; Mechothane; Mecothane; Mictone; Mictrol; Myocholine; Myotonachol; Myotonine Chloride; Urabeth; Urecholine; Urecholine Chloride; Uro-Carb; Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Mecothane: Tablet Oral Chemical IUPAC Name: 2-carbamoyloxypropyl-trimethylazanium Chemical Formula: C7H17N2O2+ Bethanechol on Wikipedia: https://en.wikipedia.org/wiki/Bethanechol Organisms Affected: Humans and other mammals