Majsolin: Full Drug Profile

Majsolin - General Information

An antiepileptic agent related to the barbiturates; it is partly metabolized to phenobarbital in the body and owes some of its actions to this metabolite. Adverse effects are reported to be more frequent than with phenobarbital. (From Martindale, The Extra Pharmacopoeia, 30th ed, p309)

Pharmacology of Majsolin

Majsolin is a barbiturate with anticonvulsant properties. Majsolin, either alone or used concomitantly with other anticonvulsants, is indicated in the control of grand mal, psychomotor, and focal epileptic seizures. It may control grand mal seizures refractory to other anticonvulsant therapy. Majsolin raises electro- or chemoshock seizure thresholds or alters seizure patterns in experimental animals. Majsolin per se has anticonvulsant activity as do its two metabolites, phenobarbital and phenylethylmalonamide (PEMA). In addition to its anticonvulsant activity, Majsolin potentiates that of phenobarbital in experimental animals.

Majsolin for patients

Patient Information:

While taking Primidone, patient should avoid alcohol and other CNS depressant.
Primidone may cause drowsiness and dizziness.
Primidone should not stopped suddently, it may results in status epilepticus.

Majsolin Interactions

No information provided.

Majsolin Contraindications

Primidone is contraindicated in:

1) patients with porphyria

2) patients who are hypersensitive to phenobarbital.

Additional information about Majsolin

Majsolin Indication: For the treatment of epilepsy Mechanism Of Action: Majsolin is a GABA receptor agonist. The mechanism of Majsolin's antiepileptic action is not known. Drug Interactions: Aminophylline The barbiturate decreases the effect of theophyllineDyphylline The barbiturate decreases the effect of theophyllineOxtriphylline The barbiturate decreases the effect of theophyllineTheophylline The barbiturate decreases the effect of theophyllineWarfarin The barbiturate decreases the anticoagulant effectAcenocoumarol The barbiturate decreases the anticoagulant effectDicumarol The barbiturate decreases the anticoagulant effectAnisindione The barbiturate decreases the anticoagulant effectBetamethasone The barbiturate decreases the effect of the corticosteroidCortisone acetate The barbiturate decreases the effect of the corticosteroidDexamethasone The barbiturate decreases the effect of the corticosteroidDivalproex sodium Valproic acid increases the effect of the barbiturateFelodipine The barbiturate decreases the effect of felodipineFludrocortisone The barbiturate decreases the effect of the corticosteroidFolic Acid Folic acid decreases the effect of anticonvulsantFelbamate Felbamate increases the effect and toxicity of primidoneGefitinib This CYP3A4 inducer may reduce gefitinib plasma concentrations and pharmacological effectsGriseofulvin The barbiturate decreases the effect of griseofulvineHydrocortisone The barbiturate decreases the effect of the corticosteroidLevonorgestrel Phenobarbital decreases the effect of levonorgestrelMethadone The barbiturate decreases the effect of methadoneMethoxyflurane The barbiturate increases the renal toxicity of methoxyfluraneMethylprednisolone The barbiturate decreases the effect of the corticosteroidMetronidazole The barbiturate decreases the effect of metronidazoleParamethasone The barbiturate decreases the effect of the corticosteroidPrednisolone The barbiturate decreases the effect of the corticosteroidPrednisone The barbiturate decreases the effect of the corticosteroidTriamcinolone The barbiturate decreases the effect of the corticosteroidVoriconazole The barbiturate decreases the effect of voriconazoleCyclosporine The barbiturate increases the effect of cyclosporineDoxycycline The anticonvulsant decreases the effect of doxycyclineMetoprolol The barbiturate decreases the effect of metabolized beta-blockerPropranolol The barbiturate decreases the effect of metabolized beta-blockerQuinidine The anticonvulsant decreases the effect of quinidineNifedipine The barbiturate decreases the effect of the calcium channel blockerVerapamil The barbiturate decreases the effect of the calcium channel blockerEthinyl Estradiol This product may cause a slight decrease of contraceptive effectMestranol This product may cause a slight decrease of contraceptive effectNorethindrone This product may cause a slight decrease of contraceptive effectChlorotrianisene The enzyme inducer decreases the effect of hormonesClomifene The enzyme inducer decreases the effect of hormonesDiethylstilbestrol The enzyme inducer decreases the effect of hormonesEstradiol The enzyme inducer decreases the effect of hormonesConjugated Estrogens The enzyme inducer decreases the effect of hormonesEstriol The enzyme inducer decreases the effect of hormonesEstrone The enzyme inducer decreases the effect of hormonesEstropipate The enzyme inducer decreases the effect of hormonesMedroxyprogesterone The enzyme inducer decreases the effect of hormonesMegestrol The enzyme inducer decreases the effect of hormonesQuinestrol The enzyme inducer decreases the effect of hormones Food Interactions: Not Available Generic Name: Primidone Synonyms: Not Available Drug Category: Anticonvulsants; Barbiturates Drug Type: Small Molecule; Approved Other Brand Names containing Primidone: Apo-Primidone; Cyral; Desoxyphenobarbitone; Hexadiona; Hexamidine; Lepimidin; Lepsiral; Liskantin; Majsolin; Medi-Pets; Midone; Milepsin; Misodine; Misolyne; Mizodin; Mizolin; Myidone; Mylepsin; Mylepsinum; Mysedon; Mysoline; Neurosyn; Pms Primidone; Prilepsin; Primacione; Primaclone; Primacone; Primakton; Primidon; Primidone Methanol Solution; Primoline; Prysoline; Pyrimidone "Medi-Pets"; Pyrimidone Medi-Pets; Resimatil; Sertan; Absorption: 90 to 100% Toxicity (Overdose): Not Available Protein Binding: 70% Biotransformation: Hepatic Half Life: 3-23 hours Dosage Forms of Majsolin: Tablet Oral Chemical IUPAC Name: 5-ethyl-5-phenyl-1,3-diazinane-4,6-dione Chemical Formula: C12H14N2O2 Primidone on Wikipedia: https://en.wikipedia.org/wiki/Primidone Organisms Affected: Humans and other mammals