Glusate
Glusate - General Information
A peptide that is a homopolymer of glutamic acid. [PubChem]
Pharmacology of Glusate
In addition to being one of the building blocks in protein synthesis, it is the most widespread neurotransmitter in brain function, as an excitatory neurotransmitter and as a precursor for the synthesis of GABA in GABAergic neurons.
Glusate for patients
It is an important excitatory neurotransmitter, and glutamic acid is also important in the metabolism of sugars and fats. It helps with the transportation of potassium across the blood-brain barrier, although itself does not pass this barrier that easily. It also shows promise in the future treatment of neurological conditions, ulcers, hypoglycemic come, muscular dystrophy, epilepsy, Parkinson's, and mental retardation. Glutamic acid can be used as fuel in the brain, and can attach itself to nitrogen atoms in the process of forming glutamine, and this action also detoxifies the body of ammonia. This action is the only way in which the brain can be detoxified from ammonia. The fluid produced by the prostate gland also contains amounts of glutamic acid, and may play a role in the normal function of the prostate.
Glusate Interactions
No well-known drug interactions with glutamic acid
Glusate Contraindications
Glutamic acid is generally free of side effects for the vast majority of people who take it; however, people with kidney or liver disease should not consume high intakes of amino acids without consulting a healthcare professional, Because over stimulation of glutamate receptors is thought to be a possible cause of certain neurological diseases (e.g., amyotrophic lateral sclerosis [Lou Gehrig�s disease] and epilepsy), people with a neurological disease should consult of physician before supplementing with glutamate.
Additional information about Glusate
Glusate Indication: Considered to be nature's "Brain food" by improving mental capacities; helps speed the healing of ulcers; gives a "lift" from fatigue; helps control alcoholism, schizophrenia and the craving for sugar.
Mechanism Of Action: Glutamate activates both ionotropic and metabotropic glutamate receptors. The ionotropic ones being non-NMDA (AMPA and kainate) and NMDA receptors. Free glutamic acid cannot cross the blood-brain barrier in appreciable quantities; instead it is converted into L-glutamine, which the brain uses for fuel and protein synthesis. It is conjectured that glutamate is involved in cognitive functions like learning and memory in the brain, though excessive amounts may cause neuronal damage associated in diseases like amyotrophic lateral sclerosis, lathyrism, and Alzheimer's disease. Also, the drug phencyclidine (more commonly known as PCP) antagonizes glutamate at the NMDA receptor, causing behavior reminiscent of schizophrenia. Glutamate in action is extremely difficult to study due to its transient nature.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: L-Glutamic Acid
Synonyms: (2S)-2-Aminopentanedioic acid; (S)-(+)-Glutamic acid; (S)-2-Aminopentanedioic acid; (S)-Glutamic acid; 1-Aminopropane-1,3-dicarboxylic acid; 2-Aminoglutaric acid; 2-Aminopentanedioic acid; a-Glutamic acid; a-Aminoglutaric acid; L-(+)-Glutamic acid; L-a-Aminoglutaric acid; L-Glutamate; L-Glutaminic acid; Glutaminic acid; Glutamic acid
Drug Category: Dietary supplement; Micronutrient; Non-Essential Amino Acids
Drug Type: Small Molecule; Nutraceutical; Approved
Other Brand Names containing L-Glutamic Acid: Aciglut; Glusate; Glutacid; Glutamicol; Glutamidex; Glutaminol; Glutaton;
Absorption: Absorbed from the lumen of the small intestine into the enterocytes. Absorption is efficient and occurs by an active transport mechanism.
Toxicity (Overdose): Glutamate causes neuronal damage and eventual cell death, particularly when NMDA receptors are activated, High dosages of glutamic acid may include symptoms such as headaches and neurological problems.
Protein Binding: Not Available
Biotransformation: Hepatic
Half Life: Not Available
Dosage Forms of Glusate: Capsule Oral
Chemical IUPAC Name: (2S)-2-aminopentanedioic acid
Chemical Formula: C5H9NO4
L-Glutamic Acid on Wikipedia: https://en.wikipedia.org/wiki/L-Glutamic_Acid
Organisms Affected: Humans and other mammals
