Exypaque

Exypaque - General Information

An effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. [PubChem]

Pharmacology of Exypaque

Exypaque is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality.

Additional information about Exypaque

Exypaque Indication: Used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures.
Mechanism Of Action: Organic iodine compounds block x-rays as they pass through the body, thereby allowing body structures containing iodine to be delineated in contrast to those structures that do not contain iodine. The degree of opacity produced by these compounds is directly proportional to the total amount (concentration and volume) of the iodinated contrast agent in the path of the x-rays. After intrathecal administration into the subarachnoid space, diffusion of iohexol in the CSF allows the visualization of the subarachnoid spaces of the head and spinal canal. After intravascular administration, iohexol makes opaque those vessels in its path of flow, allowing visualization of the internal structures until significant hemodilution occurs.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Iohexol
Synonyms: Not Available
Drug Category: Contrast Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Iohexol: Exypaque; Histodenz; Nycodenz; Omnipaque;
Absorption: Small amounts are absorbed through the bladder via Intravesical instillation. Following intrauterine instillation, the majority of the medium within the uterine cavity is discharged into the vagina immediately upon termination of procedure. However, any medium retained in the uterine or peritoneal cavity is absorbed systemically within 60 minutes. May not be absorbed for up to 24 hours if tubes are obstructed and dilated.
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Intrathecal half-life is 3.4 hours (mean). Intravascular is approximately 2 hours (with normal renal function).
Dosage Forms of Exypaque: Solution Intravascular
Solution Subarachnoid
Solution Intravascular
Chemical IUPAC Name: 5-(acetyl-(2,3-dihydroxypropyl)amino)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide
Chemical Formula: C19H26I3N3O9
Iohexol on Wikipedia: https://en.wikipedia.org/wiki/Iohexol
Organisms Affected: Humans and other mammals