Exosalt

Exosalt - General Information

Exosalt is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.

Pharmacology of Exosalt

Exosalt is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na⁺/Cl^- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.

Exosalt for patients

Tell your doctor if you have diabetes, gout, lupus, kidney or liver disease or low levels of potassium before using Exna. Avoid using Exna if you are allergic or sensitive to Exna or other sulfa drugs. Tell your dentist you are taking Exna before any dental procedure. Thiazide diuretics like Exna may cause dizziness and fatigue. Thiazide diuretics like Exna may cause hypersensitivity to sunlight. Use caution when using sauna or hot bath. It may cause dizziness, fainting, vomiting and sudden drop in blood pressure. Thiazide diuretics like Exna may result in loosing too much salt and potassium, especially among elderly women. Thiazide diuretics like Exna should not be taken with lithium, as that could increase the risk of lithium poisoning.

Exosalt Interactions

Benzthiazide may interact with alcohol, blood thinners, decongestant drugs (allergy, cold, and sinus medicines), diabetic drugs, lithium, norepinephrine, NSAIDs like Aleve or Ibuprofen, and high blood pressure medications.

Exosalt Contraindications

Contraindicated in pregnancy, sensitivity to sulfanomides, severe renal insufficiency.

Additional information about Exosalt

Exosalt Indication: For the treatment of high blood pressure and management of edema.
Mechanism Of Action: As a diuretic, benzthiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like benzthiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of benzthiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Benzthiazide
Synonyms: Not Available
Drug Category: Antihypertensive Agents; Diuretics; Stimulants
Drug Type: Small Molecule; Approved

Other Brand Names containing Benzthiazide: Aquatag; Benzothiazide; Benzthazide; Dihydrex; Diucen; Edemex; Exna; Exosalt; Fovane; Freeuril; Hydrine; Lemazide; Naclex; Pfizer 1393; Proaqua; Urese;
Absorption: Absorbed in the digestive tract.
Toxicity (Overdose): Symptoms of overdose include nausea, vomiting, fatigue, urinary problems and drowsiness.
Protein Binding: 30%
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Exosalt: Not Available
Chemical IUPAC Name: 6-chloro-1,1-dioxo-3-(phenylmethylsulfanylmethyl)-4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
Chemical Formula: C15H14ClN3O4S3
Benzthiazide on Wikipedia: Not Available
Organisms Affected: Humans and other mammals