Emdisterone
Emdisterone - General Information
Emdisterone is a potent synthetic androgenic anabolic steroid similar to testosterone. Emdisterone is indicated in postmenopausal women with recurrent breast cancer, in a combined hormone therapy.
Pharmacology of Emdisterone
Emdisterone is a synthetic androgen, or male hormone, similar to testosterone. Emdisterone works by attaching itself to androgen receptors; this causes it to interact with the parts of the cell involved in the making of proteins. It may cause an increase in the synthesis of some proteins or a decrease in the synthesis of others. These proteins have a variety of effects, including blocking the growth of some types of breast cancer cells, stimulating cells that cause male sexual characteristics, and stimulating the production of red blood cells.
Emdisterone for patients
Patients should be instructed to report any of the following: nausea, vomiting, changes in skin color, and ankle swelling.
Males should be instructed to report too frequent or persistent erections of the penis and females any hoarseness, acne, changes in menstrual periods or increase in facial hair.
Emdisterone Interactions
Androgens may increase sensitivity to oral anticoagulahts. Dosage of the anticoagulant may require reduction in order to maintain satisfactory therapeutic hypoprothrombinemia.
Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.
In diabetic patients, the metabolic effects of androgens may decrease blood glucose and therefore, insulin requirements.
Emdisterone Contraindications
- Known hypersensitivity to the drug
- Males with carcinoma of the breast
- Males with known or suspected carcinoma of the prostate gland
- Women known or suspected to be pregnant
- Patients with serious cardiac, hepatic or renal disease
Additional information about Emdisterone
Emdisterone Indication: For use in females, for palliation of androgenresponsive recurrent mammary cancer in women who are more than one year but less than five years postmenopausal.
Mechanism Of Action: Emdisterone is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone. Like testosterone and other androgenic hormones, dromostanolone binds to the androgen receptor. It produces retention of nitrogen, potassium, and phosphorus; increases protein anabolism; and decreases amino acid catabolism. The antitumour activity of dromostanolone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Dromostanolone
Synonyms: 2M-DHTP; 2MDTP; MDHT; Medrotestron propionate; Dromostanolone propionate; Dromostanolone proprionate; Drostanolone; Drostanolone propionate; Blackburn Compound
Drug Category: Anabolic Agents; Antineoplastic Agents, Hormonal
Drug Type: Small Molecule; Illicit; Approved
Other Brand Names containing Dromostanolone: Drolban; Emdisterone; Masterid; Masteril; Masteron; Masterone; Metholone; Permastril;
Absorption: Well absorbed following parenteral administration.
Toxicity (Overdose): Side effects include virilization (masculine traits in women), acne, fluid retention, and hypercalcemia.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Emdisterone: Not Available
Chemical IUPAC Name: [(2R,5S,8R,9S,10S,13S,14S,17S)-2,10,13-trimethyl-3-oxo-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl] propanoate
Chemical Formula: C23H36O3
Dromostanolone on Wikipedia: Not Available
Organisms Affected: Humans and other mammals
