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Lotrel

  • Generic Name: amlodipine besylate and benazepril hcl
  • Brand Name: Lotrel

side effects drug center lotrel (amlodipine besylate and benazepril hcl) drug - patient side effects and images

Lotrel Patient Information Including Side Effects

Brand Names: Lotrel

Generic Name: amlodipine and benazepril

What is amlodipine and benazepril (Lotrel)?

Amlodipine is a calcium channel blocker. Amlodipine relaxes (widens) blood vessels and improves blood flow.

Benazepril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Benazepril also widens blood vessels and also prevents the body from retaining water.

Amlodipine and benazepril is a combination medicine used to treat high blood pressure (hypertension).

Amlodipine and benazepril may also be used for purposes not listed in this medication guide.

What are the possible side effects of amlodipine and benazepril (Lotrel)?

Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American.

Some side effects may not occur until after you have used the medicine for several months.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • swelling in your hands or feet, rapid weight gain;
  • new or worsened chest pain;
  • fever, chills, sore throat, body aches, flu symptoms;
  • high potassium--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; or
  • liver problems--nausea, stomach pain (upper right side), itching, unusual tiredness, flu-like symptoms, dark urine, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • cough;
  • dizziness; or
  • swelling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about amlodipine and benazepril (Lotrel)?

Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away.

You should not use this medicine if you have ever had angioedema. Do not take this medicine within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).

If you have diabetes, do not use amlodipine and benazepril together with any medication that contains aliskiren (a blood pressure medicine).

Lotrel Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking amlodipine and benazepril (Lotrel)?

You should not use this medicine if you are allergic to amlodipine or benazepril, or if:

  • you have had angioedema (hives or severe swelling of deep skin tissues sometimes caused by allergic reaction);
  • you recently took a heart medicine called sacubitril; or
  • you are allergic to any other ACE inhibitor, such as captopril, enalapril, lisinopril, moexipril, benazepril, quinapril, ramipril, Accupril, Prinivil, Mavik, Vasotec, and many others.

Do not take amlodipine and benazepril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).

If you have diabetes, do not use amlodipine and benazepril together with any medication that contains aliskiren (a blood pressure medicine).

You may also need to avoid taking amlodipine and benazepril with aliskiren if you have kidney disease.

Tell your doctor if you have ever had:

Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Benazepril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

You should not breast-feed while you are using this medicine.

How should I take amlodipine and benazepril (Lotrel)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take amlodipine and benazepril with or without food. Take the medicine at the same time each day.

Vomiting, diarrhea, or heavy sweating can cause you to become dehydrated. Drink plenty of water each day while you are taking this medicine.

Your blood pressure will need to be checked often, and you may also need frequent blood tests.

If you need surgery, tell your surgeon you currently use this medicine. You may need to stop for a short time.

Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking amlodipine and benazepril. This can lead to very low blood pressure, electrolyte disorders, or kidney failure.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.

Store at room temperature away from moisture and heat.

Lotrel Patient Information including If I Miss a Dose

What happens if I miss a dose (Lotrel)?

Take the medicine as soon as you can, but skip the missed dose if you are more than 12 hours late for the dose. Do not use two doses at one time.

What happens if I overdose (Lotrel)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking amlodipine and benazepril (Lotrel)?

Drinking alcohol with this medicine can cause side effects.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Do not use salt substitutes or potassium supplements while taking amlodipine and benazepril, unless your doctor has told you to.

What other drugs will affect amlodipine and benazepril (Lotrel)?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your current medicines. Many drugs can affect amlodipine and benazepril, especially:

  • lithium;
  • probenecid;
  • simvastatin;
  • a diuretic or "water pill";
  • gold injections to treat arthritis;
  • heart or blood pressure medication;
  • insulin or oral diabetes medicine;
  • an antibiotic--clarithromycin, telithromycin;
  • antifungal medicine--itraconazole, ketoconazole;
  • antiviral medicine to treat HIV/AIDS--indinavir, ritonavir, and others;
  • medicine to prevent organ transplant rejection--cyclosporine, everolimus, sirolimus, tacrolimus, temsirolimus; or
  • NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete and many other drugs may affect amlodipine and benazepril. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information (Lotrel)?

Your pharmacist can provide more information about amlodipine and benazepril.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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