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Daytrana: Detailed Datasheet

Medically reviewed by Min Clinic Staff | Updated: January 2026

side effects drug center daytrana (methylphenidate transdermal) drug - patient side effects and images

 

PROFESSIONAL

CONSUMER

SIDE EFFECTS

Daytrana Patient Information Including Side Effects

Brand Names: Daytrana

Generic Name: methylphenidate (transdermal)

What is methylphenidate transdermal (Daytrana)?

Methylphenidate is a stimulant medicine used to treat attention deficit hyperactivity disorder (ADHD).

Methylphenidate may also be used for purposes not listed in this medication guide.

What are the possible side effects of methylphenidate transdermal (Daytrana)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using methylphenidate and call your doctor at once if you have:

  • redness, swelling, blistering, or skin color changes where the skin patch was worn (may also spread to other areas);
  • blurred vision;
  • a seizure;
  • signs of heart problems--chest pain, trouble breathing, feeling like you might pass out;
  • signs of psychosis--hallucinations (seeing or hearing things that are not real), new behavior problems, aggression, hostility, paranoia;
  • signs of circulation problems--numbness, pain, cold feeling, unexplained wounds, or skin color changes (pale, red, or blue appearance) in your fingers or toes; or
  • penis erection that is painful or lasts 4 hours or longer.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Methylphenidate can affect growth in children. Your child's height and weight may need to be checked often. Tell your doctor if your child is not growing at a normal rate.

Common side effects may include:

  • dizziness, mood swings;
  • tics;
  • nausea, vomiting, stomach pain, loss of appetite, weight loss;
  • sleep problems (insomnia); or
  • skin redness, bumps, or itching where a patch was worn.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about methylphenidate transdermal (Daytrana)?

Stimulants have caused stroke, heart attack, and sudden death in people with high blood pressure, heart disease, or a heart defect.

Methylphenidate may cause new or worsening psychosis (unusual thoughts or behavior), especially if you have a history of depression, mental illness, or bipolar disorder.

Call your doctor right away if you have: signs of heart problems--chest pain, feeling light-headed or short of breath; or signs of psychosis--paranoia, aggression, new behavior problems, seeing or hearing things that are not real.

Methylphenidate may be habit-forming. Tell your doctor if you have a history of drug or alcohol addiction. Keep the medication where others cannot get to it.

Daytrana Patient Information including How Should I Take

What should I discuss with my healthcare provider before using methylphenidate transdermal (Daytrana)?

You should not use this medicine if you are allergic to methylphenidate (Ritalin, Concerta, Metadate, and others), or if you have:

  • glaucoma;
  • tics (muscle twitches);
  • a personal or family history of Tourette's syndrome;
  • severe anxiety, tension, or agitation; or
  • if you have ever had a skin reaction to a methylphenidate skin patch.

Stimulants have caused stroke, heart attack, and sudden death in certain people. Tell your doctor if you have:

Do not use methylphenidate if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine.

Tell your doctor if you also use opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with methylphenidate could cause a serious condition called serotonin syndrome.

Tell your doctor if you have ever had:

  • a skin disorder (such as eczema, psoriasis), skin sensitivity to soaps, lotions, cosmetics, or glues;