Mitigare
- Generic Name: colchicine capsules
- Brand Name: Mitigare
- Drug Class: Antigout Agents
Mitigare (Colchicine Capsules) side effects drug center
Mitigare Side Effects Center
What Is Mitigare?
Mitigare (colchicine) is an alkaloid used to prevent gout flares in adults.
What Are Side Effects of Mitigare?
Common side effects of Mitigare include: gastrointestinal symptoms, such as:
- diarrhea
- nausea
- vomiting
- abdominal pain, and
- cramping
Dosage for Mitigare
For prophylaxis of gout flares, the recommended dosage of Mitigare is 0.6 mg once or twice daily. The maximum dose is 1.2 mg per day.
What Drugs, Substances, or Supplements Interact with Mitigare?
Mitigare may interact with clarithromycin, ketoconazole, grapefruit juice, erythromycin, verapamil, cyclosporine, HMG-CoA reductase inhibitors, and fibrates. Tell your doctor all medications and supplements you use.
Mitigare During Pregnancy and Breastfeeding
During pregnancy, Mitigare should be taken only if prescribed. This drug passes into breast milk. Consult your doctor before breastfeeding.
Additional Information
Our Mitigare (colchicine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
Mitigare Consumer Information
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- muscle pain or weakness;
- numbness or tingly feeling in your fingers or toes;
- pale or gray appearance of your lips, tongue, or hands;
- severe or ongoing vomiting or diarrhea;
- fever, chills, body aches, flu symptoms; or
- easy bruising, unusual bleeding, feeling weak or tired.
Common side effects may include:
- nausea, vomiting, stomach pain; or
- diarrhea.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Mitigare (Colchicine Capsules)
Mitigare Professional Information
SIDE EFFECTS
Gastrointestinal disorders are the most common adverse reactions with colchicine. They are often the first signs of toxicity and may indicate that the colchicine dose needs to be reduced or therapy stopped. These include diarrhea, nausea, vomiting, and abdominal pain.
Colchicine has been reported to cause neuromuscular toxicity, which may present as muscle pain or weakness [see WARNINGS AND PRECAUTIONS].
Toxic manifestations associated with colchicine include myelosuppression, disseminated intravascular coagulation, and injury to cells in the renal, hepatic, circulatory, and central nervous system. These most often occur with excessive accumulation or overdosage [see OVERDOSE].
The following reactions have been reported with colchicine. These have been generally reversible by interrupting treatment or lowering the dose of colchicine:
Digestive: abdominal cramping, abdominal pain, diarrhea, lactose intolerance, nausea, vomiting
Neurological: sensory motor neuropathy
Dermatological: alopecia, maculopapular rash, purpura, rash
Hematological: leukopenia, granulocytopenia, thrombocytopenia, pancytopenia, aplastic anemia
Hepatobiliary: elevated AST, elevated ALT
Musculoskeletal: myopathy, elevated CPK, myotonia, muscle weakness, muscle pain, rhabdomyolysis
Reproductive: azoospermia, oligospermia
To report SUSPECTED ADVERSE REACTIONS, contact Hikma Americas, Inc. at 1-800-962-8364 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Read the entire FDA prescribing information for Mitigare (Colchicine Capsules)
&Copy; Mitigare Patient Information is supplied by Cerner Multum, Inc. and Mitigare Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.