Coenzyme Q10

Coenzyme Q10 suggested uses include for angina, chronic fatigue syndrome, congestive heart failure (CHF), diabetes mellitus, doxorubicin-induced cardiotoxicity (prevention), HIV/AIDS immunostimulant, high blood pressure (hypertension), mitochondrial cytopathies, muscular dystrophies, and myopathy (statin-induced).

Coenzyme Q10 may be effective in congestive heart failure (CHF), heart attack (myocardial infarction [MI]), and mitochondrial encephalomyopathies.

Coenzyme Q10 reduces blood pressure. More studies are needed before it is recommended to treat high blood pressure (hypertension).

Studies are inconclusive on the effectiveness of coenzyme Q10 for stable angina, cardiomyopathy, and periodontal disease.

Coenzyme Q10 is available under the following different brand and other names: CoQ10, ibedenone, mitoquinone, ubidecarenone, ubiquinone, and vitamin Q10.

Suggested Dosing

50-200 mg orally daily

Congestive heart failure (CHF): 100 mg/day divided two to three times daily orally

Myocardial preservation for heart surgery: 200 mg/day orally

Dosage Considerations – Should be Given as Follows:

See “Suggested Dosing”

Side effects of Coenzyme Q10 include:

• Diarrhea
• Loss of appetite
• Elevated liver function tests (LFTs)
• Gastric distress
• Nausea
• Vomiting
• Stomach upset
• Allergic skin rashes
• Lowered blood pressure

Dividing the total daily dose of coenzyme Q10 by taking smaller amounts two or three times a day instead of a large amount all at once may help reduce side effects.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Coenzyme Q10 has no known severe, serious, or moderate interactions with other drugs.

Mild interactions of Coenzyme Q10 include:

• atorvastatin
• fluvastatin
• glyburide
• insulin aspart
• insulin detemir
• insulin glargine
• insulin glulisine
• insulin lispro
• insulin NPH
• insulin regular human
• lovastatin
• pitavastatin
• pravastatin
• rosuvastatin
• simvastatin
• tolazamide
• warfarin

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

Warnings

• This medication contains coenzyme Q10. Do not take CoQ10, ibedenone, mitoquinone, ubidecarenone, ubiquinone, or vitamin Q10 if you are allergic to coenzyme Q10 or any ingredients contained in this drug.
• Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

• None

Effects of Drug Abuse

• No information available

Short-Term Effects

• See "What Are Side Effects Associated with Using Coenzyme Q10?"

Long-Term Effects

• See "What Are Side Effects Associated with Using Coenzyme Q10?"

Cautions

• Biliary obstruction, concurrent antihypertensives, concurrent cancer chemotherapy, concurrent radiation therapy, hepatic insufficiency, and hypertension.

Pregnancy and Lactation

• There is no information available about use of coenzyme Q10 during pregnancy or while breastfeeding. Consult your doctor.