How Do CGRP Receptor Antagonists Work?

Calcitonin gene-related peptide (CGRP) receptor antagonists are drugs used for preventing episodic migraines.

CGRP is a protein that is released around the brain. When released in excess, CGRP causes intense inflammation in the coverings of the brain (meninges). Excess CGRP release in the brain aggravates the pain of a migraine attack.

CGRP receptor antagonists work as an antagonist to CGRP receptors. They bind to CGRP receptors and do not allow the binding of CGRP.

CGRP receptor antagonists are given via the intravenous route for preventive treatment of migraines.

CGRP receptor antagonists may cause the following side effects:

• Nausea
• Severe rash
• Dyspnea (shortness of breath)
• Sleepiness
• Dry mouth

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

Generic and brand names of CGRP receptor antagonists include:

• Atogepant (pending FDA approval)
• Nurtec ODT
• Rimegepant
• Ubrelvy
• Ubrogepant