How Do Adjunct Antiparkinson Agents Work?

Adjunct antiparkinson agents are indicated as add-on therapy in people with Parkinson's disease who are already on levodopa and carbidopa.

Adjunct therapy treats the symptoms of Parkinson's disease by blocking an enzyme called monoamine oxidase-type B (MAO-B). MAO-B breaks down several chemicals in the brain including dopamine. By blocking MAO-B, the drugs prevent the breakdown of dopamine, resulting in the prolonged action of dopamine in the brain. Dopamine is essential to improve the symptoms of Parkinson’s disease.

Adjunct antiparkinson agents are indicated as add-on therapy in people with Parkinson's disease who are already on other antiparkinson drugs like levodopa and carbidopa.

Some of the common side effects of adjunct antiparkinson agents include:

• Mild nausea
• Dry mouth
• Lightheadedness
• Constipation
• Confusion
• Hallucinations
• Insomnia
• Uncontrolled, involuntary muscle movements
• Anxiety
• Cough
• Indigestion
• Rash

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

Generic and brand names of adjunct antiparkinson agents include:

• Safinamide
• Xadago