Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.
Definition of MASS syndrome
Medically reviewed by Min Clinic Staff | Updated: January 2026
MASS syndrome: A heritable disorder of connective tissue characterized by involvement of the mitral valve, aorta, skeleton, and skin. Hence, the acronym MASS (Mitral valve, Aorta, Skeleton, Skin).
The MASS syndrome is due to a mutation in FBN1, the fibrillin 1 gene. The same gene as is mutated in Marfan syndrome.