Acticlate

Acticlate Side Effects Center

What Is Acticlate?

Acticlate (doxycycline hyclate) is an antibiotic used to treat rickettsial infections, sexually transmitted infections, respiratory tract infections, specific bacterial infections, ophthalmic infections, anthrax, as adjunctive therapy in acute intestinal amebiasis and severe acne, and to prevent malaria.

What Are Side Effects of Acticlate?

Common side effects of Acticlate include

anorexia,
nausea,
vomiting,
upset stomach,
diarrhea,
sensitivity to sunlight (photosensitivity),
skin rash or itching,
hives, and
vaginal itching or discharge

Dosage for Acticlate

The usual adult dose of Acticlate is 200 mg on the first day of treatment (administered 100 mg every 12 hours), followed by a maintenance dose of 100 mg daily.

What Drugs, Substances, or Supplements Interact with Acticlate?

Acticlate may interact with:

anticoagulants,
penicillin,
oral contraceptives,
barbiturates,
carbamazepine,
phenytoin,
methoxyflurane, and
antacids containing aluminum, calcium, or magnesium,
bismuth subsalicylate, and
iron-containing preparations

Tell your doctor all medications and supplements you use.

Acticlate During Pregnancy and Breastfeeding

Acticlate is not recommended for use during pregnancy. This drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Acticlate (doxycycline hyclate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

Acticlate Consumer Information

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. This reaction may occur several weeks after you began using doxycycline.

Call your doctor at once if you have:

severe stomach pain, diarrhea that is watery or bloody;
throat irritation, trouble swallowing;
chest pain, irregular heart rhythm, feeling short of breath;
little or no urination;
low white blood cell counts--fever, chills, swollen glands, body aches, weakness, pale skin, easy bruising or bleeding;
increased pressure inside the skull--severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes; or
signs of liver or pancreas problems--loss of appetite, upper stomach pain (that may spread to your back), tiredness, nausea or vomiting, fast heart rate, dark urine, jaundice (yellowing of the skin or eyes).

Common side effects may include:

nausea, vomiting, upset stomach, loss of appetite;
mild diarrhea;
skin rash or itching;
darkened skin color; or
vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Acticlate (Doxycycline Hyclate Tablets, USP)

Acticlate Professional Information

SIDE EFFECTS

The following adverse reactions have been identified during clinical trials or post-approval use of tetracycline-class drugs, including doxycycline. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Gastrointestinal

Anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, inflammatory lesions (with monilial overgrowth) in the anogenital region, and pancreatitis. Hepatotoxicity has been reported. These reactions have been caused by both the oral and parenteral administration of tetracyclines. Superficial discoloration of the adult permanent dentition, reversible upon drug discontinuation and professional dental cleaning has been reported. Permanent tooth discoloration and enamel hypoplasia may occur with drugs of the tetracycline class when used during tooth development [see WARNINGS AND PRECAUTIONS]. Instances of esophagitis and esophageal ulcerations have been reported in patients receiving capsule and tablet forms of drugs in the tetracycline-class. Most of these patients took medications immediately before going to bed [see DOSAGE AND ADMINISTRATION].

Skin

Maculopapular and erythematous rashes, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, and erythema multiforme have been reported. Photosensitivity has been reported [see WARNINGS AND PRECAUTIONS].

Renal

Rise in BUN has been reported and is apparently dose-related [see WARNINGS AND PRECAUTIONS].

Hypersensitivity Reactions

Urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis, exacerbation of systemic lupus erythematosus, and drug reaction with eosinophilia and systemic symptoms (DRESS).

Blood

Hemolytic anemia, thrombocytopenia, neutropenia, and eosinophilia have been reported.

Intracranial Hypertension

Intracranial hypertension (IH, pseudotumor cerebri) has been associated with the use of tetracyclines [see WARNINGS AND PRECAUTIONS].

Thyroid Gland Changes

When given over prolonged periods, tetracyclines have been reported to produce brown-black microscopic discoloration of thyroid glands. No abnormalities of thyroid function are known to occur.

Read the entire FDA prescribing information for Acticlate (Doxycycline Hyclate Tablets, USP)

&Copy; Acticlate Patient Information is supplied by Cerner Multum, Inc. and Acticlate Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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