Cyclogyl: Full Drug Profile

Cyclogyl - General Information

A parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia. [PubChem]

Pharmacology of Cyclogyl

Cyclogyl is an anti-muscarinic in the same class as atropine and scopolamine. Cyclogyl blocks the receptors in the muscles of the eye (muscarinic receptors). These receptors are involved controlling the pupil size and the shape of the lens. Cyclogyl thus induces relaxation of the sphincter of the iris and the ciliary muscles. When applied topically to the eyes, it causes a rapid, intense cycloplegic and mydriatic effect that is maximal in 15 to 60 minutes; recovery usually occurs within 24 hours. The cycloplegic and mydriatic effects are slower in onset and longer in duration in patients who have dark pigmented irises.

Cyclogyl for patients

Patients should be advised not to drive or engage in other hazardous activities while pupils are dilated. Patients may experience sensitivity to light and should protect eyes in bright illumination during dilation. Parents should be warned not to get this preparation in their child's mouth and to wash their own hands and the child's hands following administration. Do not touch the dropper tip to any surface as this may contaminate the solution. A transient burning sensation may occur upon instillation.

Cyclogyl Interactions

Cyclopentolate may interfere with the anti-glaucoma action of carbachol or pilocarpine; also, concurrent use of this medication may antagonise the anti-glaucoma and miotic actions of ophthalmic cholinesterase inhibitors.

Cyclogyl Contraindications

Cyclopentolate is contraindicated in patients with angle-closure glaucoma or in patients with shallow anterior chambers

Additional information about Cyclogyl

Cyclogyl Indication

Used mainly to produce mydriasis and cycloplegia for diagnostic purposes.

Mechanism Of Action

By blocking muscarinic receptors, cyclopentolate produces dilatation of the pupil (mydriasis) and prevents the eye from accommodating for near vision (cycloplegia).

Generic Name

Cyclopentolate

Synonyms

Ciclopentolato [INN-Spanish]; Cyclopentolate HCL; Cyclopentolatum [INN-Latin]; Cyclopentylate; Cyclopentoiate; Diopentolate

Drug Category

Antimuscarinic eye preparations; Muscarinic Antagonists; Mydriatics; Parasympatholytics

Drug Type

Small Molecule; Approved

Other Brand Names containing Cyclopentolate

AK-Pentolate; Akpentolate; Cyclogyl; Cylate; Minims Cyclopentolate; Mydrilate; Ocu-Pentolate; Pentolair;

Absorption

Absorbed following ophthalmic administration.

Toxicity (Overdose)

Oral LD₅₀ in the rat is 4000 mg/kg and 960 mg/kg in the mouse. Symptoms of overdose include tachycardia, dizziness, dry mouth, behavioral disturbances, uncoordination and drowsiness.

Dosage Forms of Cyclogyl

Solution / drops Ophthalmic

Chemical IUPAC Name

2-dimethylaminoethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate

Chemical Formula

C17H25NO3

Cyclopentolate on Wikipedia

https://en.wikipedia.org/wiki/Cyclopentolate

Organisms Affected

Humans and other mammals