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Convenixa: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Convenixa - General Information

An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)

 

Pharmacology of Convenixa

Paramethadione and trimethadione are anticonvulsants indicated in the control of absence (petit mal) seizures that are refractory to treatment with other medications. Dione anticonvulsants are used in the treatment of epilepsy. They act on the central nervous system (CNS) to reduce the number of seizures.

 

Convenixa for patients

 

Convenixa Interactions

 

Convenixa Contraindications

Contraindicated in liver disease, kidney disease, retinal or optic nerve (eye) disease, a disease of the blood or bone marrow, and acute intermittent porphyria.

 

Additional information about Convenixa

Convenixa Indication

Used in the control of absence (petit mal) seizures that are refractory to treatment with other medications.

Mechanism Of Action
Dione anticonvulsants reduce T-type calcium currents in thalamic neurons, including thalamic relay neurons. This raises the threshold for repetitive activity in the thalamus, and inhibits corticothalamic transmission. Thus, the abnormal thalamocortical rhythmicity, which is thought to underlie the 3-Hz spike-and-wave discharge seen on electroencephalogram(EEG) with absence seizures, is dampened.
Generic Name
Trimethadione
Synonyms
Trimethadion; Trimetadione; Trimethdione
Drug Category
Anticonvulsants
Drug Type
Small Molecule; Approved
Other Brand Names containing Trimethadione
Absentol; Absetil; Convenixa; Convexina; Edion; Epidione; Epidone; Epixal; Etydion; Mino-Aleviatin; Minoaleuiatin; Minoaleviatin; Neo-Absentol; Petidion; Petidon; Petilep; Petimalin; Pitmal; Ptimal; Tioxanona; Tredione; Tricione; Tridilona; Tridion; Tridione; Tridone; Trilidona; Trimedal; Trimedone; Trimethin; Trimetin; Trioxanona; Triozanona; Tromedone; Troxidone;
Toxicity (Overdose)
Symptoms of overdose include clumsiness or unsteadiness, coma, dizziness (severe), drowsiness (severe), nausea (severe), and problems with vision.
Protein Binding
90%
Chemical IUPAC Name
3,5,5-trimethyl-1,3-oxazolidine-2,4-dione
Chemical Formula
C6H9NO3
Organisms Affected
Humans and other mammals