Cepaverin
Cepaverin - General Information
An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
Pharmacology of Cepaverin
Cepaverin is a nonxanthine phosphodiesterase inhibitor for the relief of cerebral and peripheral ischemia associated with arterial spasm and myocardial ischemia complicated by arrhythmias. The main actions of Cepaverin are exerted on cardiac and smooth muscle. Like qathidine, Cepaverin acts directly on the heart muscle to depress conduction and prolong the refractory period. Cepaverin relaxes various smooth muscles. This relaxation may be prominent if spasm exists. The muscle cell is not paralyzed by Cepaverin and still responds to drugs and other stimuli causing contraction. The antispasmodic effect is a direct one, and unrelated to muscle innervation. Cepaverin is practically devoid of effects on the central nervous system. Cepaverin relaxes the smooth musculature of the larger blood vessels, especially coronary, systemic peripheral, and pulmonary arteries.
Cepaverin for patients
Cepaverin Interactions
No information provided.
Cepaverin Contraindications
Intravenous injection of papaverine is contraindicated in the presence of complete atrioventricular heart block. When conduction is depressed, the drug may produce transient ectopic rhythms of ventricular origin, either premature beats or paroxysmal tachycardia.
Papaverine hydrochloride is not indicated for the treatment of impotence by intracorporeal injection. The intracorporeal injection of papaverine hydrochloride has been reported to have resulted in persistent priapism requiring medical and surgical intervention.
Additional information about Cepaverin
Cepaverin Indication: For the treatment of impotence
Mechanism Of Action: Perhaps by its direct vasodilating action on cerebral blood vessels, Cepaverin increases cerebral blood flow and decreases cerebral vascular resistance in normal subjects; oxygen consumption is unaltered. These effects may explain the benefit reported from the drug in cerebral vascular encephalopathy.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Papaverine
Synonyms: Chlorhydrate de Papaverine; Papavarine Chlorhydrate; Papaverine Chlorohydrate; Papaverine Hcl; Papaverine Hydrochloride; Papaverine Monohydrochloride; Papaverinium Chloride; Papaverin
Drug Category: Vasodilator Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Papaverine: Alapav; Artegodan; Cardiospan; Cardoverina; Cepaverin; Cerebid; Cerespan; Delapav; Dilaves; Dispamil; Drapavel; Durapav; Dynovas; Forpavin; Genabid; Myobid; Optenyl; Pameion; Pamelon; Panergon; Pap H; Papacon; Papalease; Papanerin; Papanerin-Hcl; Papanerine; Papaversan; Papital T.R.; Paptial T.R.; Pavabid; Pavabid Hp; Pavacap; Pavacels; Pavacen; Pavacot; Pavadel; Pavagen; Pavakey; Pavarine; Pavased; Pavatest; Pavatine; Pavatym; Paverolan; Paveron; Pavnell; Qua Bid; Ro-Papav; Robaxapap; Spasmo-Nit; Therapav; Vasal; Vaso-Pav;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: ~90%
Biotransformation: Not Available
Half Life: 0.5-2 hours
Dosage Forms of Cepaverin: Liquid Intravenous
Chemical IUPAC Name: 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline
Chemical Formula: C20H21NO4
Papaverine on Wikipedia: https://en.wikipedia.org/wiki/Papaverine
Organisms Affected: Humans and other mammals
