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Zantryl: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Zantryl - General Information

A central nervous system stimulant and sympathomimetic with actions and uses similar to those of dextroamphetamine. It has been used most frequently in the treatment of obesity. [PubChem]

 

Pharmacology of Zantryl

Zantryl is indicated in the management of exogenous obesity as a short term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction. Zantryl hydrochloride is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for.

 

Zantryl for patients

 

Zantryl Interactions

Concomitant use of alcohol with phentermine hydrochloride may result in an adverse drug interaction.

 

Zantryl Contraindications

Advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity, or idiosyncrasy to the sympathomimetic amines, glaucoma.

Agitated states.

Patients with a history of drug abuse.

During or within 14 days following the administration of monoamine oxidase inhibitors (hypertensive crises may result).

 

Additional information about Zantryl

Zantryl Indication: For the treatment and management of obesity. Mechanism Of Action: Zantryl is an amphetamine that stimulates neurons to release or maintain high levels of a particular group of neurotransmitters known as catecholamines; these include dopamine and norepinephrine. High levels of these catecholamines tend to suppress hunger signals and appetite. Zantryl (through catecholamine elevation) may also indirectly affect leptin levels in the brain. It is theorized that phentermine can raise levels of leptin which signal satiety. It is also theorized that increased levels of the catecholamines are partially responsible for halting another chemical messenger known as neuropeptide Y. This peptide initiates eating, decreases energy expenditure, and increases fat storage. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Phentermine Synonyms: Phentermine Hcl; Phentermine Hydrochloride; (alpha,alpha)-Dimethylphenethylamine Drug Category: Adrenergic Agents; Appetite Depressants; Central Nervous System Agents; Anorexigenic Agents; Stimulants Drug Type: Small Molecule; Illicit; Approved Other Brand Names containing Phentermine: Adipex-P; Duromine; Fastin; Inoamin; Ionamin; Linyl; Lipopill; Lonamin; Mirapront; Normephentermine; Obenix; Obestin-30; Oby-Trim; Omnibex; Ona Mast; Ona-Mast; Phentercot; Phentermine Resin 30; Phentride; Pre-Sate; Pro-Fast; Teramine; Tora; Uritone; Wilpo; Wyamine Sulfate; Zantryl; Absorption: Phentermine is rapidly absorbed after oral ingestion. Toxicity (Overdose): LD50 is adult monkeys is 15 to 20 mg/kg. Symptoms of overdose include delirium, mania, self-injury, marked hypertension, tachycardia, arrhythmia, hyperpyrexia, convulsion, coma, and circulatory collapse. Protein Binding: Approximately 96.3% Biotransformation: Hepatic. Half Life: 16 to 31 hours Dosage Forms of Zantryl: Capsule Oral Chemical IUPAC Name: 2-methyl-1-phenylpropan-2-amine Chemical Formula: C10H15N Phentermine on Wikipedia: https://en.wikipedia.org/wiki/Phentermine Organisms Affected: Humans and other mammals