Xibrom: Full Drug Profile

Xibrom - General Information

Xibrom is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool to optimize surgical outcomes.

 

Pharmacology of Xibrom

Xibrom ophthalmic solution is a sterile, topical, nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use.

 

Xibrom for patients

XIBROM ophthalmic solution should not be administered while wearing contact lenses.

 

Xibrom Interactions

No information provided.

 

Xibrom Contraindications

XIBROM ophthalmic solution is contraindicated in patients with known hypersensitivity to any ingredient in the formulation.

 

Additional information about Xibrom

Xibrom Indication

For the treatment of postoperative inflammation in patients who have undergone cataract extraction.

Mechanism Of Action

The mechanism of its action is thought to be due to its ability to block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2. Prostaglandins have been shown in many animal models to be mediators of certain kinds of intraocular inflammation. In studies performed in animal eyes, prostaglandins have been shown to produce disruption of the blood-aqueous humor barrier, vasodilation, increased vascular permeability, leukocytosis, and increased intraocular pressure.

Generic Name

Bromfenac

Synonyms

Bromfenac sodium

Drug Category

Analgesics; Anti-Inflammatory Agents, Non-Steroidal

Drug Type

Small Molecule; Approved

Other Brand Names containing Bromfenac

Xibrom; Duract;

Absorption

The plasma concentration of bromfenac following ocular administration in humans is unknown.

Dosage Forms of Xibrom

Solution / drops Ophthalmic

Chemical IUPAC Name

2-[2-amino-3-(4-bromobenzoyl)phenyl]acetic acid

Chemical Formula

C15H12BrNO3

Organisms Affected

Humans and other mammals