Versapen

Versapen - General Information

Versapen is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Versapen has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Versapen results from the inhibition of cell wall synthesis and is mediated through Versapen binding to penicillin binding proteins (PBPs).

Pharmacology of Versapen

Versapen is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Versapen has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Versapen results from the inhibition of cell wall synthesis and is mediated through Versapen binding to penicillin binding proteins (PBPs).

Additional information about Versapen

Versapen Indication: Not Available
Mechanism Of Action: Versapen is a semisynthetic penicillin prodrug which itself has no antibacterial activity, but is converted in the body to ampicillin and has actions and uses similar to those of ampicillin. Versapen is prepared by reacting ampicillin with acetone. Ampicillin rapidly decomposes because of the intramolecular attack of the side chain amino group on the lactam ring. Versapen locks up the offending amino group and prevents the decompolsition Versapen, once hydrolyzed to ampicillin (and acetone) binds to the penicillin binding proteins found in susceptible bacteria. This inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Hetacillin
Synonyms: Not Available
Drug Category: Anti-Bacterial Agents; Penicillins
Drug Type: Small Molecule; Approved

Other Brand Names containing Hetacillin: Hetacillin potassium; Versapen; Versapen-k;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Hydrolyzed to active ampicillin via esterases
Half Life: Not Available
Dosage Forms of Versapen: Not Available
Chemical IUPAC Name: (2S,5R,6R)-6-[(4R)-2,2-dimethyl-5-oxo-4-phenylimidazolidin-1-yl]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Chemical Formula: C19H23N3O4S
Hetacillin on Wikipedia: https://en.wikipedia.org/wiki/Hetacillin
Organisms Affected: Enteric bacteria and other eubacteria