Vantin

Vantin - General Information

Vantin is an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis.

Pharmacology of Vantin

Vantin is an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria. Notable exceptions include Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis.

Additional information about Vantin

Vantin Indication: For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms.
Mechanism Of Action: Vantin is active against a wide spectrum of Gram-positive and Gram-negative bacteria. Vantin is stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and cephalosporins, due to their production of beta-lactamase, may be susceptible to cefpodoxime. Vantin is inactivated by certain extended spectrum beta-lactamases. The bactericidal activity of cefpodoxime results from its inhibition of cell wall synthesis.
Drug Interactions: Not Available
Food Interactions: Take on empty stomach: 1 hour before or 2 hours after meals.
Generic Name: Cefpodoxime
Synonyms: Cefpodoxime proxetil; CPDX-PR
Drug Category: Cephalosporins; Antibacterial Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Cefpodoxime: Vantin; Banan; Doxef; Orelox; Otreon; Podomexef;
Absorption: Cefpodoxime proxetil is a prodrug that is absorbed from the gastrointestinal tract and de-esterified to its active metabolite, cefpodoxime. Following oral administration of 100 mg of cefpodoxime proxetil to fasting subjects, approximately 50% of the administered cefpodoxime dose was absorbed systemically.
Toxicity (Overdose): Not Available
Protein Binding: 22 to 33% in serum and from 21 to 29% in plasma.
Biotransformation: Not Available
Half Life: 2.09 to 2.84 hours
Dosage Forms of Vantin: Tablet, film coated Oral
Granule, for suspension Oral
Chemical IUPAC Name: (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Chemical Formula: C15H17N5O6S2
Cefpodoxime on Wikipedia: https://en.wikipedia.org/wiki/Cefpodoxime
Organisms Affected: Enteric bacteria and other eubacteria